386,595 papers found

A method for a meta-analysis of several environmental or occupational epidemiological studies with small prevalences and/or incidences and long latency periods is presented. A combination of statistical evaluations of small prevalences should be done in the following way: (1) selecting relevant and comparable studies,…

AIMS/INTRODUCTION: Despite there being several meta-analyses on the effects of antidiabetic agents in patients with gestational diabetes mellitus, the reliability of their findings is a concern, mainly due to undetermined methodological quality of these studies. This study aimed to assess the methodological quality of…

OBJECTIVES: This study aimed to compare the impacts of different nutritional supplements and drugs on older adults with sarcopenia. DESIGN: Systematic review and network meta-analysis. SETTING AND PARTICIPANTS: Participants with sarcopenia receiving nutritional and pharmacological interventions targeting sarcopenia i…

The use of systemic tetracycline in the treatment of periodontal disease has been controversial. To investigate this controversy, we performed a quality assessment and attempted to perform a meta-analysis of 13 published studies. We evaluated the quality of the study protocol and data analysis and presentation for each…

OBJECTIVE: --To assess the efficacy of intrathecal therapy with tetanus antibody (antitetanus equine serum or human tetanus immune globulin) in neonatal and adult tetanus using meta-analytical techniques. DATA SOURCES: --Clinical trials identified by searching MEDLINE and by reviewing bibliographies of published artic…

Bivariate random-effects models represent a recommended approach for meta-analysis of diagnostic test accuracy, jointly modeling study-specific sensitivity and specificity. As the severity of the disease status can vary across studies, a proper analysis should account for the dependence of the accuracy measures on the…

A recent meta-analysis claimed decreasing prospective effects of acting with awareness and non-reacting, two facets of dispositional mindfulness, on subsequent anxiety and depressive symptoms. However, the meta-analytic cross-lagged effects were estimated while adjusting for a prior measurement of the outcome variable…

Elucidating the genetic components of plant genotype-by-environment interactions is of key importance in the context of increasing climatic instability, diversification of agricultural practices and pest pressure due to phytosanitary treatment limitations. The genotypic response to environmental stresses can be investi…

Most airborne contaminants have minimal health effects at typical ambient levels, and this is especially true for contaminant levels in the Arctic. Among multiple studies of similar health effects, usually only one or two of the studies show statistically significant effects. Only after an attempt to quantitatively com…

BACKGROUND: Degenerative spondylolisthesis (DS) is a common cause of low back pain and lumbar spinal stenosis, necessitating various surgical interventions. Traditional management includes fusion surgery, but recently decompression with or without dynamic stabilization has been explored. However, the relative efficacy…

For analysis of the main effects of SNPs, meta-analysis of summary results from individual studies has been shown to provide comparable results as "mega-analysis" that jointly analyzes the pooled participant data from the available studies. This fact revolutionized the genetic analysis of complex traits through large G…

A meta-analytic approach was used to summarize studies of cancer incidence among Native populations in the United States and Canada. Native males and females were found to have a significantly lower incidence of cancer for all sites combined. Among Native males, kidney cancer was found to exhibit significantly elevated…

BACKGROUND: Primary dysmenorrhea (PD) is characterized by a cramping pain in the lower abdomen during menstruation. Acupuncture-related therapy is frequently used to treat patients with PD. We conducted a network meta-analysis to compare the efficacy and safety of acupuncture-related therapies based on Korean and Chine…

PURPOSE: To summarize and analyze all the evidence available concerning marginal bone loss (MBL) and implant failure between tilted and axial implants. MATERIALS AND METHODS: An electronic literature search was conducted without any language restrictions, and only systematic reviews with meta-analysis or meta-analysis…

BACKGROUND: Insomnia is a common problem after a stroke, affecting daily life and the recovery process. Among the many Traditional Chinese Medicine(TCM) nursing techniques, it is still unknown which measures are most effective. OBJECTIVE: To evaluate the efficacy of different TCM nursing techniques on post-stroke inso…

BACKGROUND: The efficacy of nonpharmacological therapies for patients with gastroesophageal reflux disease (GERD) has been progressively proved. However, the specific differences in effectiveness among various nonpharmacological interventions and their combinations with pharmacological interventions remain unclear, and…

BACKGROUND AND PURPOSE: Episodic migraine is a neurological disorder characterized by recurrent, unilateral headaches that significantly impair quality of life. CGRP monoclonal antibodies, targeting calcitonin gene-related peptide (CGRP), have shown efficacy in preventing and treating episodic migraine. METHODS: A sys…

Many authors have published their results of first metatarsal osteotomies to reduce the intermetatarsal angle. Each study has shown some degree of success. The meta-analysis or research synthesis that follows is a method of providing a quantitative review of these studies. It is a procedure for aggregating numerous stu…