376,100 papers found

Protamine insulin use may immunologically sensitize patients to protamine, leading to anaphylactoid reactions upon subsequent exposure to protamine sulfate during cardiac catheterization or cardiovascular surgery. The risk of such reactions in protamine insulin-dependent patients is uncertain. One catheterization study…

Both epidemiologic and clinical studies have suggested that an increase in potassium intake may lower blood pressure. However, the results of prospective clinical trials looking at the effect of oral potassium supplements on blood pressure have yielded conflicting results. For this reason, we reviewed 19 clinical trial…

In the past 10 years there has been growing awareness among occupational health professionals worldwide of the large burden of illness associated with musculoskeletal disorders of the neck and upper limbs. It has been suggested that these disorders are associated with highly repetitive work and are due, at least in par…

OBJECTIVE: To evaluate the efficacy and safety of anlotinib combined with programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors in the treatment of malignant solid tumors. METHODS: PubMed, Web of Science, Embase, and Cochrane Library databases were searched to collect randomized controlled…

BACKGROUND: Keloids are pathological scars causing pain, pruritus, and emotional distress. While common treatments exist, emerging options such as insulin and botulinum toxin A (BTX-A) are underrepresented in comparative analyses. This network meta-analysis (NMA) aimed to evaluate the efficacy and safety profiles of va…

OBJECTIVE: This network meta-analysis aimed to compare and rank the efficacy and safety of acupuncture-related therapies (ARTs) for polycystic ovary syndrome (PCOS) in improving insulin resistance (IR), reproductive endocrine outcomes, and ovarian morphology. METHODS: Randomized controlled trials (RCTs) in Chinese and…

OBJECTIVE: The clinical benefits of neurostimulation therapies for treating dysphagia in acute and critical care patients remain controversial. This study aims to comprehensively review the literature to assess the effectiveness of neurostimulation therapies. METHODS: Databases including PubMed, Cochrane Library, Emba…

BACKGROUND: Arts-based interventions are increasingly employed to alleviate anxiety and depression among college students; however, their relative effectiveness across modalities remains unclear. This study aimed to compare the efficacy of diverse arts-based approaches for improving mental health outcomes in this popul…

BACKGROUND: Frailty in older adults is a common aging-related syndrome that can lead to adverse health outcomes. Although physical exercise and nutritional interventions have been widely recognized as beneficial for managing frailty, the comparative effectiveness of various intervention approaches remains uncertain. O…

AIMS/HYPOTHESIS: Insulin therapy is essential for managing hyperglycaemia in type 2 diabetes mellitus when oral or non-insulin injectable agents are no longer effective. However, the comparative effectiveness and safety of different insulin regimens remain uncertain. We aimed to compare the effects of basal, basal-bolu…

BACKGROUND AND OBJECTIVE: Metastatic hormone-sensitive prostate cancer (mHSPC) patients with visceral disease (VD) represent a high-risk subgroup associated with poor prognosis. Despite the introduction of treatment intensification strategies, the optimal systemic therapy for these patients remains unclear. This networ…

BACKGROUND: The optimal endovascular method to treat infrapopliteal chronic limb-threatening ischemia (CLTI) remains to be determined, given the limitations of stent use in infrapopliteal artery disease. We performed a network meta-analysis (NWM) of randomized controlled trials (RCTs) to simultaneously compare the outc…

BACKGROUND: Previous network meta-analyses have focused on individuals with dementia or intervention delivery formats. The comparative effectiveness of reminiscence-based therapies in older adults without diagnosed mild cognitive impairment (MCI) or dementia remains unclear. This study aimed to identify which reminisce…

BACKGROUND: Severe lupus nephritis (LN) remains difficult to manage despite standard immunosuppressive therapy. Immunoadsorption (IA) has been increasingly used as an adjunctive treatment. However, comparative evidence across different IA columns is limited. METHODS: We conducted a systematic review and Bayesian netwo…

Patients with borderline personality disorder (BPD) are over-represented in psychiatric services, and their suicide mortality is markedly higher than that of the general population. This network meta-analysis evaluated and compared the efficacy and safety of pharmacological treatments for symptoms of BPD. A systematic…

BACKGROUND: Breast cancer is the most prevalent cancer among women worldwide and poses significant challenges because of its high incidence and treatment-related sequelae. Although the benefits of physical exercise across treatment phases are well documented, evidence specifically assessing its effects during chemother…

BACKGROUND: The optimal hypoabsorptive surgical approach for management of severe obesity remains unclear. AIM: To perform a network meta-analysis (NMA) of randomized clinical trials (RCTs) comparing Roux-en-y gastric bypass (RYGB), SADI-S (single anastomosis duodeno-ileal bypass with sleeve gastrectomy), one anastomo…

BACKGROUND: Percutaneous left atrial appendage occlusion (LAAO) is a non-pharmacological strategy to prevent stroke and systemic emboli in patients with non-valvular atrial fibrillation (AF). However, data regarding its safety and efficacy profile compared to different oral anti-coagulant regimens remain limited. METH…

AIMS: Obesity, one of the most frequent health risks, represents a global public health problem. The potential impact of L-carnitine, a vital nutrient for energy metabolism, on weight loss is worth considering. However, given the inconclusive results from recent meta-analyses on L-carnitine, we conducted an umbrella me…

BACKGROUND: Cancer cachexia is a severe metabolic syndrome marked by skeletal muscle atrophy. A successful clinical intervention for cancer cachexia is currently lacking. The study of cachexia mechanisms is largely based on preclinical animal models and the availability of high-throughput transcriptomic datasets of cac…