Pharmacological and non-pharmacological treatments for irritable bowel syndrome: Protocol for a systematic review and network meta-analysis.
Zhou Shenghui, Liu Xiaoli, Wang Xiaoxia, +4 more·Medicine
BACKGROUND: The global prevalence of Irritable bowel syndrome (IBS) is estimated to be as high as 15% and a number of different non-pharmacological and pharmacological treatments have been used to manage IBS in clinical practice, which poses great challenges for clinicians to make appropriate decisions. Hence, a system…
OBJECTIVE: The aim of this systematic review with meta-analysis is to determine the effect of miniscalpel-needle/needle-knife in treatment of chronic pain symptoms.
METHODS: The following electronic databases will be searched by 2 independent reviewers: PubMed, Cochrane Library, EMBASE, Springer, China National Knowle…
Which is the optimal adjuvant chemotherapy for resected pancreatic ductal adenocarcinoma?: A protocol for a network meta-analysis of randomized controlled trials.
Hu Qiancheng, Wang Xin, Chen Ye, +3 more·Medicine
BACKGROUND: Although adjuvant chemotherapy has been shown to reduce relapse and prolong survival after surgery, it is still unclear which adjuvant chemotherapy regimen will be favorable over the all adjuvant treatments evaluated for patients with resected pancreatic ductal adenocarcinoma.
METHODS: PubMed, Embase (Ovid…
Prognositic significance of P-cadherin expression in breast cancer: Protocol for a meta-analysis.
Xi Yupeng, Zhang Xiwen, Yang Zizhen, +6 more·Medicine
BACKGROUND: P-cadherin is a calcium-dependent cell-cell adhesion glycoprotein. It has been implicated in invasiveness and metastasis. However, the clinical prognostic value of overexpression of P-cadherin in patients with breast cancer (BC) remains unsettled.
METHODS: A systematic literature search will be performed i…
Validation of miRNA prognostic significance in stage II colorectal cancer: A protocol for systematic review and meta-analysis of observational clinical studies.
BACKGROUND: Advances in early detection and treatment of colorectal cancer (CRC) has seen marked improvements in recent years. However, it is still the third leading cause of cancer-related deaths worldwide. Although there are studies reporting the significance of miRNAs in stage II colorectal cancer, there is no known…
Comparison between video-assisted thoracoscopic lung cancer resection and robot-assisted lung cancer resection: Protocol for a systematic review and meta-analysis.
Chai Tianci, Lin Yuhan, Shen Zhimin, +6 more·Medicine
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) has developed rapidly and a variety of feasible technical methods have been formed. VATS is the main way of lung cancer resection nowadays with minor surgical incision and less bleeding. Robot-assisted thoracic surgery (RATS) is a revolution in surgical procedures…
Health outcomes in offspring of mother with breast implants: A protocol of systematic review and meta-analysis.
Song Ailin, Dang Jie, He Zhiyun, +5 more·Medicine
BACKGROUND: An increasing number of women undergo breast augmentation at their reproductive age. The most existing evidence focuses on the impact of breast implant on the index women's health and breastfeeding after they give birth to a child. No previous systematic review has investigated the association between breas…
The effect of post mastectomy radiation therapy on breast reconstruction with and without acellular dermal matrix: a systematic review and meta-analysis protocol.
Chung Amy M, Stein Michael J, Ghumman Ammara, +1 more·Systematic reviews
BACKGROUND: The widespread implementation of acellular dermal matrix (ADM) has broadened the reconstructive repertoire for alloplastic breast reconstruction. ADM's role in the context of postoperative radiation therapy remains unclear. The present review will evaluate whether ADM reduces complication rates in patients…
Herbal medicine (Zhengan Xifeng Decoction) for essential hypertension protocol for a systematic review and meta-analysis.
Huang Yonglian, Chen Yanhong, Cai Hairong, +10 more·Medicine
BACKGROUND: Essential hypertension is one of the most common chronic diseases worldwide, as well as a leading risk factor for cardiocerebrovascular diseases. Zhengan Xifeng Decoction (ZGXFD) has been widely used to treat essential hypertension, but there is no systematic review by assessing efficacy and safety of ZGXFD…
Ventilator for the treatment of acute respiratory distress syndrome: A protocol for systematic review and meta-analysis.
Gao Yan, He Ya-Long·Medicine
BACKGROUND: Ventilator has been reported to treat acute respiratory distress syndrome (ARDS). However, its efficacy is still inconclusive. This systematic review and meta-analysis study aims to evaluate its efficacy and safety for the treatment of patients with ARDS.
METHODS: The electronic databases of Cochrane centr…
Banxia Baizhu Tianma decoction for hyperlipidemia: Protocol for a systematic review and meta-analysis.
Cai Hairong, Guo Yongning, Zhao Zicong, +3 more·Medicine
BACKGROUND: Hyperlipidemia is one of the most common metabolic diseases worldwide, as well as a leading risk factor for cardio-cerebrovascular diseases. Banxia Baizhu Tianma decoction (BBTD) is widely used for the treatment of hyperlipidemia in China, however, systematic review and meta-analysis regarding its efficacy…
The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not all, of the studies. We investigate the benefits of including varying proportions of IPD studies in…
Economic analysts are increasingly likely to rely on systematic reviews and meta-analyses of health state utility values to inform the parameter inputs of decision-analytic modelling-based economic evaluations. Beyond the context of economic evaluation, evidence from systematic reviews and meta-analyses of health state…
Impact of inhalational anesthetics on postoperative cognitive function: Study protocol of a systematic review and meta-analysis.
Zou Yi-Qing, Li Xiao-Bao, Yang Zhi-Xing, +5 more·Medicine
BACKGROUND: Conflict findings of the impact of inhalational anesthetics on postoperative cognitive function are reported. No systematic review has been performed to solve the problem. The aim of the study was to assess the effect of different inhalational anesthetics on postoperative cognitive function in a network met…
Electroacupuncture for postoperative pain management after total knee arthroplasty: Protocol for a systematic review and meta-analysis.
Xiong Jie, Li Huiying, Li Xiaoya, +5 more·Medicine
BACKGROUND: Total knee arthroplasty (TKA) is one of the most common joint replacement surgeries in the United States. Postoperative pain is still a major complication after TKA. Electroacupuncture (EA) has been commonly used in clinical practice for pain after TKA, but its effects and safety remain uncertain. This prot…
Meta-analysis is not an exact science: Call for guidance on quantitative synthesis decisions.
Haddaway Neal R, Rytwinski Trina·Environment international
Meta-analysis is becoming increasingly popular in the field of ecology and environmental management. It increases the effective power of analyses relative to single studies, and allows researchers to investigate effect modifiers and sources of heterogeneity that could not be easily examined within single studies. Many…
Enhanced recovery after surgery (ERAS) programs for esophagectomy protocol for a systematic review and meta-analysis.
Liu Feiyu, Wang Wei, Wang Chengde, +1 more·Medicine
BACKGROUND: Esophageal cancer is one of the worst malignant digestive neoplasms with poor treatment outcomes. Esophagectomy plays an important role and offers a potential curable chance to these patients. However, esophagectomy with radical lymphadenectomy is known as one of the most invasive digestive surgeries which…
Association between daily life experience and psychological well-being in people living with nonpsychotic mental disorders: Protocol for a systematic review and meta-analysis.
Ho Jeffery, Ngai Shirley P C, Wu William K K, +1 more·Medicine
BACKGROUND: Evidence has shown that people living with nonpsychotic mental disorders experience difficulties in maintaining their daily living, consequently impacting on psychological well-being. However, the role of daily life experience remains unclear. This systematic review and meta-analysis aims to determine the a…
Psychological interventions for the treatment of depression, anxiety, alcohol misuse or anger in armed forces veterans and their families: systematic review and meta-analysis protocol.
BACKGROUND: Evidence highlights a high prevalence of common mental health disorders in armed forces veterans and their families, with depression, anxiety, alcohol misuse and anger being more common than PTSD. This paper presents a protocol for a systematic review and meta-analysis to identify existing randomised contro…