391,922 papers found

A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for alcohol consumption and cigarette smoking. Five studies included in the meta-analysis of alcohol consumption. Alcohol consumption was computed in terms of average weekly intake, measu…

The effect of verapamil on death and major events (i.e., death or reinfarction) after an acute myocardial infarction was studied in a double-blind, randomized, placebo-controlled, multicenter trial, the Danish Verapamil Infarction Trial II (DAVIT II). Eight hundred seventy-eight patients started treatment with verapami…

PURPOSE: To determine whether corticosteroids affect short-term mortality from alcoholic hepatitis. DATA IDENTIFICATION: Studies published from 1966 to 1989 were identified through a MEDLINE computer search and an extensive manual search of the bibliographies of identified articles. STUDY SELECTION: We found 11 rando…

Whereas coronary angioplasty has been demonstrated to be unnecessary and perhaps harmful for most patients after successful thrombolytic treatment of acute myocardial infarction, the clinical benefit of rescue angioplasty after failed thrombolysis remains untested in a randomized clinical trial. However, in the clinica…

Twelve published clinical results of radical radiotherapy of head and neck cancer have been reviewed, seven of them with fresh multivariate analyses, to determine the magnitude of time factors relating local control to overall time. In all but two of the data sets a significant loss of local control was observed with p…

In the literature on neonatal encephalopathy, the pervasive assumption is that once infants with major malformations or infections have been excluded, most of the remaining cases are due to birth asphyxia. Assessing the proportion of neonatal encephalopathy that is due to asphyxia during birth is difficult because of p…

This paper develops a method for estimating the odds ratio in a case-control study that 'borrows' strength from the controls in similar previous studies. We assume that the observations within each stratum in the current study are generated from a pair of independent binomial distributions. We assume that the observati…

A metaanalysis of the major clinical trials on the benefits of antihypertensive therapy revealed that there is an overall reduction of coronary events by treatment, but that it is only about one-half of the reduction predicted. The reduction in stroke achieved the predicted number. This "failure" has been attributed to…

The authors analyzed data from two recent articles in Radiology in which the quality and results of randomized control trials (RCTs) comparing the efficacy or safety of the low-osmolality contrast media (LOM) iopamidol, iohexol, and ioxaglate with that of the high-osmolarity contrast media (HOM) diatrizoate, iodamide,…

The power of the association between oral contraceptives and breast cancer was analysed in all the papers published up to date. Seventy-seven publications (from 44 studies) were collected and graded as to quality using meta-analytical methods. Power achieved a figure of greater than or equal to 0.8 in a 10.8% of the as…

Original papers on the oral contraceptive use-cervical cancer relationship are analysed. The purpose of this study was to ascertain the biases of the original articles collected in relation to various characteristics of any investigation. Papers were located by using MEDLINE, reviewing the references of each article id…

Existing empirical literature on the prolonged or cumulative consequences of exposure to the stresses of caregiving is reviewed. Specific goals are to identify psychiatric and physical morbidity effects, report the magnitude of those effects, evaluate research and analytic methods used to assess morbidity, and make rec…

With a common study protocol, case-referent studies within cohorts were performed in Denmark, Norway, Sweden, and Finland to study reproductive hazards of women doing dry-cleaning work. Due to national differences not all of the studies could follow exactly the same procedures in data collection, but they were all base…

Meta-analytic procedures were used to assess the degree to which aggression-related cues present in the environment facilitate aggressive responding among negatively aroused subjects. The first study, which examined the so-called weapons effect, the effect of name-mediated cues, and other cue effects, showed clear evid…

Psychosocial and sexual disturbances are common sequelae to a diagnosis of breast cancer and its treatment. The hope that the development of breast-conserving techniques would protect women from the psychological distress experienced after mastectomy has not been realized. Studies comparing the psychosocial outcome of…

Every hospital doctor will be aware of the importance of correct documentation. We are concerned with quality assurance because this provides an aid towards optimising treatment results and also enables multi-centre comparisons to be made. The set of data used for three years during the pilot study provides the basis f…

INTRODUCTION: Proton-pump inhibitor (PPI) monotherapy is standard for artificial ulcer healing after gastric endoscopic submucosal dissection, but evidence on the efficacy of PPI combined with gastric mucosal protectants remains inconclusive. This network meta-analysis aimed to compare the efficacy of 10 mucosal protec…

PURPOSE: This network meta-analysis aimed to evaluate and rank the comparative efficacy of aerobic training (AT), resistance training (RT), combined AT and RT (CT), and high-intensity interval training (HIIT) primarily on body weight and secondarily on body mass index (BMI), fat-free mass, fasting glucose, fasting insu…

Optimally, syringe-filling technique may reduce the risk of post-injection endophthalmitis (PIE), yet there is wide variation between ophthalmologists and jurisdictions regarding syringe-filling practices. This frequentist network meta-analysis (PROSPERO: CRD42024555196) of rare events sought to compare the odds of PIE…

PURPOSE: This systematic review aims to evaluate and synthesize the existing literature on the interventions used for submacular haemorrhage (SMH), highlighting the controversies and differences in clinical practice. METHOD: A systematic review was conducted following the PRISMA guidelines. A comprehensive search was…