98,297 papers found

Three hundred ninety-nine cemented stem revision total hip arthroplasties performed in cases with mechanical stem failure without infection and having a minimum follow-up period of 3 years were prospectively studied. Two hundred eighty-three were revised for aseptic stem loosening and 116 were revised for fractured ste…

A total of 4664 bacteriological analyses of the wound and purulent discharge from orthopedo-traumatological patients were performed within a 6-year period, i.e. from 1971 to 1976. Staphylococci were the dominating microbes of the purulent-inflammatory foci. Its part in the monoculture amounted to 64.5--82 per cent. The…

The goal of this study was to evaluate the frequency and timing of "do not resuscitate" (DNR) orders among pediatric oncology patients with progressive solid tumors. A retrospective evaluation of the medical charts of 36 patients who died in our department over the last 4 years was made. There were 21 males and 15 fema…

Accurate fingerprinting of critical raw materials that have significant impact on process performance and product quality is a necessary precursor for implementation of QbD in process and product development. This article presents a review of major developments in this space in the last 10 years, with a special emphasi…

Over the last 5 years a number of articles have been published on gene therapy for a range of diseases. The initial tone of a number of these articles evoked high expectations, particularly from the public. Over the last 2-3 years data from these studies have begun to filter through and, perhaps not surprisingly, initi…

Necrotizing enterocolitis (NEC) is an important cause of neonatal morbidity and mortality. During the last few years, there was an increase in the incidence of this disease, associated with a better knowledge of NEC, and an increase in survival rate, associated with the development, even from a technological point of v…

Radiotherapy may cause valvular (VHD), pericardial, coronary artery disease (CAD), left ventricular dysfunction (LVD), arrhythmias. The risk of radiation induced heart disease (RIHD) increases over time. The current guidelines suggest a screening for RIHD every 5 years in the long-term survivors who had been treated by…

BACKGROUND: Little is known regarding healthcare expenditures for patients with dementia with Lewy bodies (DLB) during the end of life. OBJECTIVE: This study estimated Medicare expenditures during the last 5 years of life in a decedent sample of patients who were clinically diagnosed with Alzheimer's disease (AD) or D…

BACKGROUND: Dermatologists face a litany of professional and legal risks in practice. OBJECTIVE: To review cases of disciplinary and legal action against dermatologists in Canada. METHODS: The Canadian Medical Protective Association, all 10 provincial medical colleges, and the Canadian Legal Information Institute wer…

During the last 5 years, new randomized trials in critically ill patients have challenged a number of traditional treatment strategies in intensive care. The authors review eight studies that helped change their medical practices.

BACKGROUND: Decrease in mortality due to cardiovascular diseases during last years seems to be a widespread phenomenon in industrialized countries. This study analyses the evolution of mortality due to cardiovascular diseases in Andalucía, Spain, from 1975 to 1992. The analysis has been carried out for ischemic he…

INTRODUCTION AND AIMS: Although the incidence of emphyema is increasing it continues to be a widely debated pathology in relation to its management. We analyzed the last 36 cases treated by our service in the last 2 years. MATERIAL AND METHODS: We retrospectively studied the last 36 cases of parapneum6nic pleural effu…

INTRODUCTION: Globus pallidus internus (GPi) deep brain stimulation (DBS) represents a validated, effective, and safe treatment for patients affected by generalized dystonia resistant to conservative treatment. Segmental and multisegmental dystonia have more recently been proposed as further indications for GPi DBS des…

AIM: Preliminarily we analyzed the rate incidence of organic and psychological causes of erectile dysfunction in large cohort of patients observed during last year. Particularly we wanted to analyze the factors of risk correlated to the vascular erectile dysfunction. METHODS: The epidemiological study has been conduct…

Three female patients aged 30,55 and 4 years had large tumour-like masses, which were progressively increasing in size for the last 4,5 and 4 years respectively. Excision of these lesions and histopathlology revealed mature fat cells in the middle, and lower dermis, interspersed between collagen bundles and surrounding…

AIMS: Our original study, the first national prospective study of new-onset heart failure from heart muscle disease in children, showed overall 1-year survival of 82%, and event (death or transplantation)-free survival of 66%. This study aimed to evaluate 5 + year outcomes of this important cohort. METHODS AND RESULTS…

Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. Ganoderma meroterpenoids (GMs) are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated terpenoid part. Over last 5 years, great efforts have been made to conduct phytochemistry resear…

In contrast with the growing interest in dissociative disorders over the last few years, depersonalization continues to be very scarcely approached. There is no agreement among clinicians regarding the concept of depersonalization, and little is known about its etiology, epidemiology and treatment. This paper has two m…

Our understanding of eukaryotic protein folding in the endoplasmic reticulum has increased enormously over the last 5 years. In this review, we summarize some of the major research themes that have captivated researchers in this field during the last years of the 20th century. We follow the path of a typical protein as…

To evaluate when it is possible to discontinue anticonvulsant treatment in children with cryptogenic partial epilepsy, the authors studied 89 epileptic children divided into two groups: Group A, 45 children whose therapy was discontinued after 1 year from the last seizure; and Group B, 44 children whose therapy was sto…