381,602 papers found

Applied Hedges and Olkin's (1985) statistical meta-analytic procedures to summary data from all published studies that compared behavioral weight-control programs that formally involved partners in treatment (couples programs) to similar programs in which subjects participated alone (subject-alone programs). Based on t…

INTRODUCTION: The aim of this systematic review was to assess the available evidence related to the effectiveness of stepwise excavation (SW) or selective excavation (SE) when compared to non-selective caries excavation (NSE) for the management of permanent teeth with deep carious lesions without signs of irreversible…

BACKGROUND: Non-invasive brain stimulation (NIBS) techniques have emerged as a promising tool for understanding and treating psychiatric disorders, necessitating a caution in terms of interpreting research results. OBJECTIVE: This study aimed at systematically evaluating a representative sample of research conducted u…

OBJECTIVE: The primary objective of this study was to estimate the cost effectiveness of treating diabetic foot ulcers with becaplermin (Regranex) plus good wound care (GWC) compared with GWC alone in a variety of European healthcare settings. A secondary objective was to analyse the effect of different treatment pract…

OBJECTIVE: To determine, by a quantitative meta-analysis of randomized trials, the effectiveness of strategies to improve patient compliance with screening, referral, and clinic appointments for health services that are provided at the time of the visit. DATA SOURCES: Computerized searches of MEDLINE (1966 through 199…

For 50 years, the key to successfully preventing venous thrombosis (VT) or pulmonary embolism (PE) among high-risk patients has been the judicious use of anticoagulants: first through full doses of oral anticoagulants and more recently through low-dose heparin prophylaxis. Low-dose heparin has become the standard of co…

BACKGROUND: The unprecedented emergence of the COVID-19 pandemic necessitated the development and global distribution of vaccines, making the understanding of global vaccine acceptance and hesitancy crucial to overcoming barriers to vaccination and achieving widespread immunization. OBJECTIVE: This umbrella review syn…

BACKGROUND: The efficacy of psychopharmacological treatments has been called into question. Psychiatrists are unfamiliar with the effectiveness of common medical drugs. AIMS: To put the efficacy of psychiatric drugs into the perspective of that of major medical drugs. METHOD: We searched Medline and the Cochrane Libr…

The purpose of this paper is twofold. The first is to analyse the statistical relationship between real health care expenditure per capita and aggregate income, public share in finance, age-dependency ratio and inflation. The second purpose deals with methodological problems involved in pooling health care expenditure…

Over the past year, concerns regarding breast cancer screening guidelines and the benefits of mammography have been raised. These concerns were fueled by a leak of information from the Canadian National Breast Screening study that suggested first an increase in mortality in women aged 40 to 49 years and then, after fur…

PURPOSE: For decades the treatment of choice in small-cell lung cancer (SCLC) with brain metastases has been corticosteroids and radiotherapy (RT) because of a presumed lack of penetrance of cytostatic agents into parenchymatous brain metastases. In recent years, several reports have appeared on radiologic and clinical…

OBJECTIVE: The rapid, efficient, and accurate communication of clinical research findings to both clinicians and researchers is essential to the process of improving medical care. This information should be conveyed in a form that facilitates the interpretation of the complete body of research on a specific condition.…

Parkinson's disease (PD) surveys and death-record studies in European populations were reviewed. Particular attention was given to methodological aspects. Two sets of quality criteria were used. Four door-to-door surveys revealed underdiagnosis of prevalent idiopathic parkinsonism ranging from 30% to 71%. Quality surve…

Essential hypertension, a widespread health problem, is commonly treated with palliative medications. Pessimism in the medical community about behavioral treatments including biofeedback derives from early evaluations of interventions using relatively weak interventions. Current relations-based interventions using self…

Since metformin became available for therapeutic utilisation, more than 30 years ago, it has been found that the compound was able to reduce hyperglycaemia in diabetic subjects without any stimulation of B cell secretion. The mechanism(s) of action of this drug has been better clarified these last 5-10 years even if al…

Most recent clinical research studies on wear of posterior composite restorations have used the USPHS and Leinfelder measuring techniques. New studies are adopting the Moffa-Lugassy (M-L) technique. However, to date there has been no means of comparing results of the different techniques. The objective of this study wa…

We conducted a combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer. Our analysis shows a consistent, statistically significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women (relative risk for highest…

BACKGROUND: Hypertension is a significant risk factor for cardiovascular disease on a global scale, particularly among middle-aged and elderly individuals. Hypertension is not only associated with cardiovascular disease, including heart disease and stroke, but also leads to vascular endothelial dysfunction and decrease…

BACKGROUND: Reduced saturated fat (SFA) consumption is recommended to reduce coronary heart disease (CHD), but there is an absence of strong supporting evidence from randomized controlled trials (RCTs) of clinical CHD events and few guidelines focus on any specific replacement nutrient. Additionally, some public health…

BACKGROUND: Previous work has suggested that dual blockade using inhibitors of the renin-angiotensin system (RAS) would be associated with an increase in side effects compared to monotherapy. We reexamined the safety of dual RAS blockade, especially in patients at risk, and explored the stability of the evidence accumu…