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Strapkova A, Antosova M·Bratislavske lekarske listy
BACKGROUND: The interest of arginase action is increasing because limitation of L-arginine bioavailability by arginase for NO synthesis via constitutive NOS can contribute to airway hyperreactivity. OBJECTIVES: We investigated the effect of intervention in the arginase activity in guinea pig model of experimental oval…
Sutovska M, Franova S, Sutovsky J·Bratislavske lekarske listy
BACKGROUND: The ATP-sensitive potassium ion channels (K+ATP) are widely expressed on airway sensory nerves that mediate cough and other protective reflexes; dependent on airways smooth muscles (ASM) reactivity. OBJECTIVE: The study was conducted to determine the involvement of K+ATP in airway sensory nerves activity o…
Hujová Z, Desatnikova J, Gabor D·Bratislavske lekarske listy
BACKGROUND: Atherosclerosis could develope in the presence of CVD risk factors in early age. OBJECTIVE: To determine some risk factors of Cardiovascular Disease in Gypsy children and adolescents from Central Slovakia. PARTICIPANTS: Study population (Gypsy/Caucasian ethnicities) consisted of 198 Gypsy children and ado…
Bucova M, Bernadic M, Buckingham T·Bratislavske lekarske listy
Inflammation of vascular cell wall is the key problem and proinflammatory cytokines and chemokines play a great role in it. These molecules, togheter with C-reactive protein (CRP) can predict risk of coronary events. It is questionable to what extend are CRP and pro-inflammatory cytokines purely acute phase markers and…
Mokra D, Calkovska A, Tonhajzerova I, +3 more·Bratislavske lekarske listy
BACKGROUND: In this study, the effects of single and repetitive dexamethasone administration on lung functions in meconium-instilled rabbits were compared. In addition, short-term adverse effects of dexamethasone on blood pressure, heart rate, and heart rate variability were evaluated. METHODS: Artificially ventilated…
Treska V, Skalicky T, Houdek K, +1 more·Bratislavske lekarske listy
BACKGROUND: The incidence of liver injury is increasing steadily because of serious injuries resulting mainly from traffic accidents. The aim of the study was to evaluate the results of the University Trauma Center, with consideration of the present diagnostic and therapeutic possibilities for liver injuries. METHODS:…
Rajec J, Tisonova J, Kriska M, +6 more·Bratislavske lekarske listy
OBJECTIVES: The aim of the study was to determine the amount of circulating endothelial cells (CECs) in patients with an advanced cardiovascular (CV) disease, compare the values with a control group and finally to ascertain if there are statistically significant differences within the studied patient groups. BACKGROUN…
Rao R M, Dharmarajan A M, Rao A J·Apoptosis : an international journal on programmed cell death
Placenta is a transient feto-maternal association that develops during mammalian pregnancies. Human placental tissue during the first trimester of pregnancy is an actively dividing and differentiating tissue, while near term, it represents a fully differentiated unit performing many life-sustaining functions for the fe…
Hafifah Ifa, Wisesrith Wasinee, Ua-Kit Noraluk, +1 more·Indian journal of palliative care
Understanding the definition of a good death in the intensive care unit (ICU) is crucial for the effective implementation of end-of-life care. Existing reviews often focus on terminal patients and overlook the ICU setting. This study aimed to investigate the definitions of a good death in the ICU. The systematic review…
Lo Torto Federico, Firmani Guido, Patanè Luca, +4 more·Microsurgery
BACKGROUND: Supermicrosurgical flaps based on perforator-to-perforator microanastomoses have been described for lower limb reconstruction. This approach offers the benefit of raising short pedicles while sparing axial vessels, which effectively enables complex reconstructive techniques in comorbid patients at high risk…
Horvathova M, Jahnova E, Szabova M, +5 more·Bratislavske lekarske listy
The purpose of this study was to investigate the modulation of selected cell surface markers and proinflammatory cytokines production in relation to ageing, and cigarette smoking. The analysis of cell surface receptors was performed by the flow cytometry and cytokines levels were evaluated by the sandwich enzyme immuno…
Uzun Y, Akdogan E, Ozdemir F, +1 more·Bratislavske lekarske listy
BACKGROUND: Patients with cancer are frequently treated with anticoagulants, including heparin, to prevent or to treat the deep vein thrombosis. It has been indicated that heparin affects the survival of patients with cancer. Also, the apoptotic and antiproliferative effects of heparin on some cancers has been demonstr…
Rybar I, Rozborilova E, Zanova E, +3 more·Bratislavske lekarske listy
BACKGROUND: New biologic therapies blocking TNF undoubtly constitute a considerable advancement in the management mentioned diseases, but are also associated with higher risk of activation of tuberculosis. METHODS: An assessment of tuberculosis activation rate in the group of patients with rheumatoid arthritis, juveni…
Brozmanova M, Bartos V, Plank L, +2 more·Bratislavske lekarske listy
There is many evidence that inhalation of high oxygen concentration has a toxic influence on pulmonary function and structures. Hyperoxia-induced oxidative stress is well characterized in rodents and has been used as a valuable model of human respiratory distress syndrome. We have previously shown that hyperoxic exposu…
Pereska Z, Dejanova B, Bozinovska C, +1 more·Bratislavske lekarske listy
BACKGROUND: Long-term heroin abuse is related to pathological changes in many organs mediated by oxidative stress (OS). OBJECTIVES: Estimation of systemic OS and antioxidant capacity in heroin addiction and detoxification provides information about prooxidant/antioxidant homeostasis in heroin misuse and need for antio…
Nalbant Selim, Sahan Burak, Durna Murat, +4 more·Bratislavske lekarske listy
OBJECTIVES: Investigate the role of cytokines in Behçet uveitis. BACKGROUND: Cytokines may take part in this pathogenetic mechanism. Elevated and/or altered levels of specific cytokines have been found in patients with Behçet's disease in many studies. METHODS: Twenty patients with Behçet uveitis and 2…
Schwartz Alan, Millam Gregory, UIC LCS Investigators·BMC medical informatics and decision making
BACKGROUND: Incorporating evidence based medicine (EBM) into clinical practice requires clinicians to learn to efficiently gain access to clinical evidence and effectively appraise its validity. Even using current electronic systems, selecting literature-based data to solve a single patient-related problem can require…
Tubbs-Cooley Heather L, Riddle Sarah W, Gold Jennifer M, +8 more·Journal of advanced nursing
AIM: To describe paediatric postdischarge concerns manifesting in the first 96 hr after hospital discharge. DESIGN: Analysis of nursing documentation generated as part of a randomized controlled trial evaluating the effect of a nurse home visit on healthcare re-use. METHODS: We analysed home visit records of 651…
Taylor Sasha, Islam Rakibul M, Bell Robin J, +2 more·Clinical endocrinology
OBJECTIVE: To explore the associations between endogenous testosterone blood concentrations and muscle mass, strength and performance in community dwelling women. DESIGN, PATIENTS AND MEASUREMENTS: Online databases, including Ovid MEDLINE, EMBASE and Web of Science, were searched for observational studie…
Tauseef Abubakar, Zafar Maryam, Silberstein Peter, +9 more·Journal of family medicine and primary care
INTRODUCTION: With an increase in number of cases of relapsed or refractory multiple myeloma (RRMM), scientist have discovered various combination of medications among which one is daratumumab, Daratumumab is a mono-clonal antibody which attacks CD-38 markers present in abundance on the surface of myeloma cells and is…