376,100 papers found

Chronic delta hepatitis is a severe disease with a rapidly progressive course for which currently no effective treatment exists. Treatment with alpha-interferon (alpha-IFN) can inhibit HDV replication and improve serum chemistries in a number of patients. Meta-analysis of five randomized controlled trials using at leas…

A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for alcohol consumption and cigarette smoking. Five studies included in the meta-analysis of alcohol consumption. Alcohol consumption was computed in terms of average weekly intake, measu…

The effect of verapamil on death and major events (i.e., death or reinfarction) after an acute myocardial infarction was studied in a double-blind, randomized, placebo-controlled, multicenter trial, the Danish Verapamil Infarction Trial II (DAVIT II). Eight hundred seventy-eight patients started treatment with verapami…

The natural history of cranial dural arteriovenous malformations (AVM's) is highly variable. The authors present their clinical experience with 17 dural AVM's in adults, including 10 cases with an aggressive neurological course (strictly defined as hemorrhage or progressive focal neurological deficit other than ophthal…

OBJECTIVE: To compare the efficacy and safety of different anti-vascular endothelial growth factor (anti-VEGF) agents in combination with pars plana vitrectomy (PPV) for the treatment of proliferative diabetic retinopathy (PDR), in order to guide clinical decision-making. METHODS: A systematic search was conducted in…

BACKGROUND: Obesity is a major modifiable risk factor for atherosclerotic cardiovascular disease. This study evaluated the efficacy of different exercise modalities in improving vascular health parameters in overweight/obese adults. METHODS: We conducted a systematic review and network meta-analysis of 51 randomized c…

INTRODUCTION: Glucagon receptor agonists (GRAs) are an emerging class of therapies for obesity and type 2 diabetes, demonstrating encouraging metabolic and weight-reducing effects. Several investigational GRA-based agents, including retatrutide, cotadutide, mazdutide, and survodutide, have reported promising results ac…

BACKGROUND: The trigger digit is a mechanical condition in which the finger snaps, triggers, or locks due to a thickened retinacular sheath at the A1 pulley. OBJECTIVE: To evaluate the effectiveness of different treatment options for the trigger finger and thumb. METHODS: We searched PubMed, Embase, and Cochrane Libr…

BACKGROUND: Cutaneous warts are exophytic, benign proliferative lesions caused by human papillomavirus infection of basal keratinocytes. Many intralesional immunomodulatory agents are used by dermatologists these days including Bacillus Calmette-Guerin vaccine, measles-mumps-rubella vaccine, purified protein derivative…

OBJECTIVE: To conduct a network meta-analysis to compare the efficacy and safety of various surgical strategies for refractory obsessive-compulsive disorder (OCD), including ablative surgery (ABL) and deep brain stimulation (DBS), with the aim to guide clinical treatment. METHODS: We searched major electronic database…

OBJECTIVE: To compare intraorifice barrier materials for reinforcing endodontically treated teeth using a network meta-analysis of in vitro studies. METHODS: EBSCO, PubMed, Virtual Health Library, Ovid, Web of Science, Scopus, Cochrane Library, and Google Scholar were searched to December 2025. Eligible studies compar…

BACKGROUND: The therapeutic effects of different combination therapies containing cholesteryl ester transfer protein (CETP) inhibitors vary. Evidence from head-to-head comparisons is scarce and inconsistent. This study aimed to evaluate the impact of CETP inhibitor-based combination therapy on lipid levels and explore…

STATEMENT OF PROBLEM: Existing evidence suggests that conventional and bulk-fill resin composites (RCs) do not fully restore the physiological fracture resistance of teeth with extensive MOD cavities, leaving posterior restorations susceptible to bulk fracture, particularly in structurally compromised or endodontically…

OBJECTIVE: Nonpharmacological (alternative) interventions (NPIs) for pain relief during vaginal delivery have gained popularity, as adjuncts to pharmacological interventions or as primary treatment. METHODS: We searched PubMed/Medline, EMBASE, and Ovid Discovery for observational trials published through May 2024. Thi…

OBJECTIVE: To identify the optimal whole-body vibration training (WBVT) mechanical vibration frequency for enhancing muscle strength, static balance, dynamic balance, and gait performance among older adults through systematic review and network meta-analysis. DATA SOURCES: PubMed, Web of Science, Cochrane Library, Emb…

The majority of reported complex disease associations for common genetic variants have been identified through meta-analysis, a powerful approach that enables the use of large sample sizes while protecting against common artifacts due to population structure and repeated small-sample analyses sharing individual-level d…

OBJECTIVE: To describe the relative risk for serious gastrointestinal complications due to non-aspirin nonsteroidal anti-inflammatory drug (NSAID) exposure among NSAID users as well as in selected subgroups. DESIGN: Overview and meta-analysis. DATA IDENTIFICATION: A literature search of English-language studies exami…

INTRODUCTION: Mind-body therapies (MBTs) have demonstrated beneficial effects on anxiety, depression, and sleep quality in college students. However, few studies have compared the efficacy of different types of MBTs. Therefore, we conducted this study to compare and rank the relative effects of various MBTs on these ou…

The association between different air pollutants and Type 2 Diabetes Mellitus (T2DM) is a growing topic of interest in public health research. This umbrella review and meta-analysis aimed to consolidate current literature on the association between various outdoor air pollutants and T2DM. Subgroups and dose-response re…

AIM: To evaluate the diagnostic accuracy of all brief multidomain alternatives to the Mini-Mental State Examination (MMSE) in the detection of dementia. METHODS: A literature search, critical appraisal, and meta-analysis were conducted of robust diagnostic validity studies involving cognitive batteries. Twenty-nine di…