376,100 papers found

OBJECTIVE: To compare the efficacy and safety of different anti-vascular endothelial growth factor (anti-VEGF) agents in combination with pars plana vitrectomy (PPV) for the treatment of proliferative diabetic retinopathy (PDR), in order to guide clinical decision-making. METHODS: A systematic search was conducted in…

Cancer-related complications pose significant challenges in the management and treatment of patients with malignancies. Several meta-analyses have indicated improving effects of probiotics on cancer complications, while some studies have reported contentious findings. The purpose of the present study was to evaluate th…

BACKGROUND: Sphingosine-1-phosphate receptor modulators (S1PRM) are used to treat relapsing multiple sclerosis (MS). Each drug has a different S1PR-subtype selectivity. They target the G-protein coupled S1P receptors and exert significant immunomodulatory effects, such as preventing the formation of new CNS lesions and…

BACKGROUND: The optimal antithrombotic strategy for secondary prevention in patients with atrial fibrillation (AF) and concomitant atherosclerotic cardiovascular disease (ASCVD) following acute ischemic stroke (IS) remains undefined. This network meta-analysis aimed to compare the efficacy and safety of oral anticoagul…

INTRODUCTION: Pharmacological therapies are recommended for individuals with obesity. Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1), and tirzepatide, a dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist (GIP/GLP-1), are among the leading pharmacological options for obesity tr…

BACKGROUND: Pacing strategy is a key determinant of endurance performance, enabling athletes to regulate effort to optimise outcomes. While various pacing profiles (e.g. self-selected, fast-start, even, or slow) have been proposed, their comparative effects on performance remain unclear because of conflicting findings…

BACKGROUND: The comparative efficacy of brief behavioral therapy for insomnia (BBTI) remains unclear. AIMS: This systematic review and network meta-analysis examined the effectiveness of different BBTI approaches and compared BBTI with other nonpharmacological interventions, such as cognitive behavioral therapy for in…

STUDY DESIGN: An Umbrella Review and Meta-analysis. OBJECTIVE: This umbrella review and meta-analysis aims to evaluate the efficacy of stem cell therapy for locomotion recovery and neuropathic pain alleviation in rodent models of spinal cord injury (SCI). METHODS: A comprehensive literature search was conducted in Me…

BACKGROUND: Physical activity is important for healthy ageing, however most older adults are inactive. Numerous reviews with a range of inclusion criteria have been conducted on digital interventions to promote physical activity in older adults, and a synthesis of these is needed. Therefore, the objective of this study…

OBJECTIVES: To overview and summarize the results emerging from the studies on adjunctive devices (AD) with theoretical anti-embolic properties in patients with ST-elevation acute myocardial infarction (STEMI) undergoing percutaneous coronary interventions (PCI). BACKGROUND: A series of small-to-medium size randomized…

OBJECTIVE: To define the benefit of rice oral rehydration salts solution in relation to the glucose based World Health Organisation oral rehydration salts solution for treating and preventing dehydration in patients with severe dehydrating diarrhoea. DESIGN: Meta-analysis using data from 13 available randomised trials…

OBJECTIVE: A comprehensive meta-analysis of clinical trial data was performed to assess the possible association of fluoxetine and suicidality (suicidal acts and ideation). DESIGN: Retrospective analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder comparing fluoxetine…

BACKGROUND: Sleep problems are common among older adults and are associated with a wide range of adverse health outcomes. Concerns about pharmacological treatments have increased interest in non-pharmacological interventions; however, evidence comparing their relative effectiveness remains limited. METHODS: A systemat…

BACKGROUND: Sweet solutions are widely used to reduce procedural pain in preterm infants, but their comparative efficacy and safety remain unclear. METHODS: We searched CINAHL, MEDLINE, Embase, CENTRAL, Scopus, and ProQuest for randomized controlled trials comparing glucose, sucrose, or expressed breast milk with cont…

Previous work suggests that key factors for replicability, a necessary feature for theory building, include statistical power and appropriate research planning. These factors are examined by analyzing a collection of 12 standardized meta-analyses on language development between birth and 5 years. With a median eff…

Radiolabeled antibodies for cancer therapy are being investigated in clinical trials in more than 30 centers. 131Iodine-labeled antibody (Ab) therapy of solid tumors has produced few responses when given alone. When given in conjunction with chemotherapy and external beam therapy in hepatoma patients, objective respons…

Since 1952, 20 datasets have been generated through 17 studies in an attempt to describe the sources and importance and/or use of information about pharmaceuticals by physicians. The authors review the findings of the studies and subject them to three sequentially relevant, but different, meta-analytic procedures. The…

Left-handedness occurs in about 8% of the human population. It runs in families and an adoption study suggests a genetic rather than an environmental origin; however, monozygotic twins show substantial discordance. The only genetic models that successfully explain the family and twin data are those of McManus and Annet…

Sonography and CT were used pre-operatively for lymph node staging in patients with head and neck malignancies. The accuracy of the imaging methods surpassed that of palpation (palpation 85%, CT 85%, sonography 90%). Sensitivity was significantly increased from 74% (palpation) to 84% (CT) and 90% (sonography), ie. ther…

An overview of eight randomized controlled trials of tissue-type plasminogen activator (Alteplase or Duteplase) and 10 of anisoylated plasminogen streptokinase activator complex (Anistreplase) showed that the odds of early death were reduced by 29% by tissue-type plasminogen activator and 46% by anisoylated plasminogen…