376,100 papers found

BACKGROUND AND OBJECTIVE: To evaluate the association between glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and intestinal cancers and to explore the risk factors for these associations. METHODS: PubMed, Embase, Web of Science, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrial…

BACKGROUND: Youth aged 15-24 years carry a disproportionate HIV/sexually transmitted infections (STIs) burden. In recent years, different modalities of digital health interventions (DHIs) have been explored to promote safer sex behaviors among youth, but their comparative effectiveness across modalities and relative to…

Multiple reviews have examined the impact of nutritional interventions in patients with burn injuries; however, discrepancies among results cast doubt about their validity. We implemented this review to assess the impact of various nutritional interventions in adult patients with burn injuries. We conducted a thorough…

Optimization of radiation therapy for head and neck tumors requires the combination of several facets of radiation biology and physics. The aim is to achieve optimum tumor control while reducing normal tissue damage. Techniques have been developed to determine tumor radiosensitivity and growth characteristics. Their us…

In order to evaluate the variability in the diagnostic accuracy of the exercise electrocardiogram, a meta-analytic database derived from a review of 147 publications and a multicenter database derived from 2,826 angiographic referrals were analyzed. Wide variability in sensitivity and specificity were found from the me…

We systematically reviewed the six articles from the English-language medical literature, since 1979, which compared 99mTc-RBC venography with contrast venography for the diagnosis of deep venous thrombosis (DVT) of the lower extremity. The studies were generally small in size and poorly compliant with methodologic sta…

Age at the start of breast development and at menarche are important maturity indicators in adolescent females. Breast development is usually the first event of puberty and menarche virtually the last. Irregularities in the age of the subject at their appearance can denote a lack of synchronisation between pubertal eve…

Because fungal infection is a significant factor that determines the morbidity and the mortality of many patients with cancer, it is essential to understand the various predisposing defects that lead to such infections. These defects may be categorized into two broad areas: immune defects and mechanical defects. Among…

We conducted a survey of clinical trials to assess the scientific evidences presented for the practical use of dinitrochlorobenzene, squaric acid dibutylester, and diphencyprone in the treatment of alopecia areata. Twenty-six papers published between January 1977 and January 1988, in English, French, and Italian were s…

Due to the recent development of absorbable surgical staples, application of gynecologic stapling methods has expanded to the field of obstetrics. Several studies have been published presenting the results of utilization of a novel hysterotomy and uterine stapling device for cesarean section (Poly CS-57, U.S. Surgical…

: Intermittent fasting (IF) shows promise for metabolic and mental health benefits, but evidence in older adults remains limited. This study systematically evaluated the safety and effectiveness of IF in adults aged ≥60 years, comparing different protocols using network meta-analysis.: Systematic review and netw…

INTRODUCTION: Mediastinal and/or hilar lymphadenopathy (MHL) has become more frequently identified. Despite advances in endobronchial ultrasound (EBUS)-guided sampling, evidence on the optimal modality is lacking. This systematic review and network meta-analysis aimed to compare the diagnostic performance and safety of…

BACKGROUND: This study employed a network meta-analysis to systematically compare the efficacy and safety of different endovascular interventions for treating isolated popliteal lesions in peripheral arterial disease. METHODS: A systematic search was conducted across the Cochrane Library, Embase, and PubMed databases…

PURPOSE: This network meta-analysis aimed to evaluate and rank the comparative efficacy of aerobic training (AT), resistance training (RT), combined AT and RT (CT), and high-intensity interval training (HIIT) primarily on body weight and secondarily on body mass index (BMI), fat-free mass, fasting glucose, fasting insu…

BACKGROUND AND AIMS: Primary biliary cholangitis is a chronic cholestatic liver disease that may progress to cirrhosis and liver failure. For patients with inadequate response or intolerance to ursodeoxycholic acid, peroxisome proliferator-activated receptor (PPAR) agonists have emerged as second-line options. This stu…

BACKGROUND: Despite surgically successful total knee arthroplasties, up to 20% of patients are dissatisfied postoperatively. A factor thought to influence dissatisfaction is the alignment strategy utilized. Inconsistencies in safe zone definitions between neutral and kinematic alignment strategies have limited previous…

OBJECTIVE: To review published reports of risk of breast cancer with oral contraceptive use. DESIGN: Meta-analysis of study results, using regression techniques to explore the inter-study heterogeneity. SETTING: Twenty-seven epidemiological studies of breast cancer risk and oral contraceptive use published 1980-1989.…

Fibrosis is a key predictor of the long-term prognosis in metabolic dysfunction-associated steatotic liver disease (MASLD). Numerous clinical trials in drug development for MASLD have used fibrosis improvement as an efficacy endpoint. We aim to compare the efficacy of pharmacologic therapies for MASLD in improving fibr…

To compare the effects of continuous positive airway pressure (CPAP), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), their combination, and no active intervention on respiratory, sleepiness, and metabolic outcomes in adults with obstructive sleep apnea (OSA). We searched PubMed, Embase, and CENTRAL through Augu…

INTRODUCTION: Crowther et al. 3 analysed the effectivity of magnesium tocolysis in preventing preterm birth. They conclude that there is no evidence for protection. In its latest guidelines, based on this Cochrane analysis, the German Association of Gynaecology and Obstetrics (DGGG) does not recommend any more the use…