391,940 papers found

BACKGROUND AND OBJECTIVE: Randomized clinical trials (RCTs) provide the most reliable estimates of treatment effectiveness for therapeutic interventions. However, flaws in their design and conduct may bias treatment effect estimates, leading to overestimation or underestimation of the true intervention effect. This is…

BACKGROUND: Despite an increasing number of publications on Peyronie's disease (PD), evidence-based clinical decision-making remains challenging due to the small number of well-designed clinical trials. AIM: To perform a critical analysis of reporting quality in PD systematic reviews (SR) and meta-analyses (MA). METH…

PURPOSE: Imeglimin (Imeg), a novel oral antidiabetic drug that acts as a mitochondrial modulator and targets multiple metabolic pathways, offers a novel therapeutic option for type 2 diabetes mellitus (T2DM). Although both Imeg and dipeptidyl peptidase-4 inhibitors (DPP-4i) enhance glucose-stimulated insulin secretion…

Bacille Calmette-Guérin osteomyelitis in infants is a known complication of Bacille Calmette-Guérin vaccination. Treatment consists of antituberculosis chemotherapy after biopsy/curettage; however, in cases of Bacille Calmette-Guérin osteomyelitis extending to the growth plate and epiphysis, the extent a…

OBJECTIVE: To evaluate the efficacy of pharmacological treatment of apathy in patients with neurodegenerative diseases. METHODS: Systematic review of studies assessing the effects of pharmacological treatment on apathy in neurodegenerative diseases. RESULTS: Thirty-five studies were included: 2 meta-analyses, 13 rand…

OBJECTIVES: Statistics on prevalence of pneumoconiosis among working underground coal miners based on epidemiologic data collected between 1960 and 1988 are presented. The main intent was to examine the time-related trend in prevalence, particularly after 1969, when substantially lower dust levels were mandated by fede…

Lacidipine is a calcium antagonist of the dihydropyridine group that is highly selective for vascular tissues. It has been tested during the last few years for the treatment of arterial hypertension. We evaluated the clinical position of this calcium antagonist on the basis of clinical results. From the dose-ranging st…

There is now agreement about the clinical features of panic disorder and agoraphobia but less agreement about treatment because of controversy over whether the disorder is primarily biological or psychological. The authors were requested to produce an impartial review for continuing education and peer review. We chose…

Prior qualitative literature reviews about the use of neuroleptics in dementia suggest that they are "modestly effective" in treating agitation and that no single neuroleptic is better than another. To develop a more precise concept of the clinical efficacy of neuroleptics, a metaanalytic review of the existing literat…

Numerous interventional studies have revealed the beneficial impact of curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers, but the findings are still inconsistent. Thus, this study was conducted to investigate the effects of curcumin supplementation on inflammation, oxidativ…

BACKGROUND: Epidemiologic studies link oral contraceptive use with several cardiovascular events, but the literature is difficult to summarize, and potential biases remain poorly addressed. This study uses meta-analysis to summarize study results and to analyze the influence of study characteristics, including suscepti…

AIMS: This network meta-analysis of randomized controlled trials (RCTs) evaluates the comparative safety and efficacy of intra-coronary (IC) pharmacological and procedural treatments-on top of balloon angioplasty and stent placement-on clinical outcomes and surrogate endpoints of coronary microvascular obstruction (CMV…

BACKGROUND: Placing a pulp-capping material over the remaining dentine is integral to managing deep carious lesions in permanent teeth without pulp exposure. However, current guidelines do not favour any specific pulp-capping material, and there is no direct clinical evidence that pulp-capping materials maintain pulp v…

IMPORTANCE: Differences in treatment effects between men and women may have important implications across diverse interventions and diseases. OBJECTIVES: We aimed to evaluate claims of sex-based differences in treatment effects across published meta-analyses. ELIGIBILITY CRITERIA: Published meta-analyses of randomise…

The increasing prevalence of cyberbullying victimization has become a commonplace issue globally. Although research has explored various predictors and consequences of cyberbullying victimization, most focus on a narrow range of variables or contexts, highlighting the need to comprehensively review and synthesize the w…

Peer-reviewed publications and conference proceedings are the mainstay of data sources for systematic reviews and network meta-analyses (NMA), but access to informative unpublished data is now becoming commonplace. To explore the usefulness of three types of 'grey' literature-clinical trials registries, clinical study…

PURPOSE: Infection control is particularly vital in hospitals, and proper use of antimicrobial drugs is one of the most important roles of hospital pharmacists. In this study, we surveyed patients who had been prescribed single-use ciprofloxacin (CPFX), and evaluated the blood concentration of CPFX from the predictive…

The association of Fcgamma receptor (FcgammaR) polymorphisms with systemic lupus erythematosus (SLE) has been demonstrated in various populations; however, the results have been inconsistent. We recently identified a single-nucleotide polymorphism encoding a non-synonymous substitution, Ile232Thr (I232T), of FCGR2B and…

BACKGROUND: A statistically appropriate analysis of the association between survival and response measures in patients with ovarian cancer could help to define the role of response rate in planning, monitoring, and interpreting the results of clinical trials. PURPOSE: This study was designed to investigate the relatio…