Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 1,301–1,320 · 1797 ms
Wilson L A, McKechnie A A·Scottish medical journal
Abstract not available
Arkins J A, Hirsch S R·The Journal of allergy
Abstract not available
Rapp S, Carter C H·The Journal of new drugs
Abstract not available
Alexander W D, Harden R M, Koutras D A, +1 more·Lancet (London, England)
Abstract not available
Luo Deyan, Pan Hongxing, He Peng, +24 more·Clinical and translational medicine
BACKGROUND: To determine an appropriate dose of, and immunization schedule for, a vaccine SCoK against COVID-19 for an efficacy study; herein, we conducted randomized controlled trials to assess the immunogenicity and safety of this vaccine in adults. METHODS: These randomized, double-blind, placebo-controlled phase 1…
Chowdhary U M, Sayed K·Journal of neurology, neurosurgery, and psychiatry
A comparative controlled clinical trial of epsilon aminocaproic acid (EACA), 36 g/day and tranexamic acid (TEA), 6 g/day, was undertaken to assess their effectiveness in reducing early recurrence of subarachnoid haemorrhage (SAH). Of 90 patients treated with EACA recurrent haemorrhage was seen in 8% of these patients a…
Morelli A, Pelli A, Narducci F, +1 more·Scandinavian journal of gastroenterology. Supplement
The effectiveness of pirenzepine in the treatment of gastric ulcer was assessed in a double-blind 6 weeks' clinical trial in comparison with placebo. After 2 weeks of treatment 1 patient in each group showed a complete healing of gastric ulcer. After 6 weeks of treatment 9 out of 10 patients in the pirenzepine group (9…
Gowdey C W, Hamilton J T, Philp R B·Canadian Medical Association journal
An exercise for medical students was designed to illustrate one method of setting up a clinical trial and incidentally to demonstrate some effects of placebos. Twelve groups of four students participated: one in each group was the "recorder", the other three (volunteers) were randomly assigned to the treatment A, treat…
Abramson N S, Safar P·Annals of emergency medicine
Deferred consent, a new approach to the requirement for informed consent in clinical research, was used in a randomized clinical trial of brain resuscitation after cardiac arrest. Because patients were comatose and therapy had to be initiated immediately, traditional prospective consent usually could not be obtained. U…
Donnan M F, Ball I A·British dental journal
Abstract not available
Lykkegaard-Nielsen M, Madsen P V, Nielsen O V·Diseases of the colon and rectum
Sequential analysis of a double-blind clinical trial involving 26 patients demonstrated a statistically significant superiority of ceruletide over metroclopramide in restoring peristalsis in intestinal paralysis after abdominal surgery (P less than 0.05).
Layfield D J, Walker A K·Anaesthesia
In 60 children aged 1-9 years, weighing under 33 kg, oral trimeprazine and oral trimeprazine plus droperidol were compared as premedicants in a controlled, double-blind clinical trial. The addition of droperidol to the trimeprazine syrup produces greater uniformity in pre-operative sedation, a low incidence of postoper…
Yong C C·International journal of dermatology
The results of an open clinical trial of 200 patients in Singapore show that benzoyl peroxide, in a stable gel formulation, both in 2.5% and 5% strengths, was highly efficacious in the topical treatment of acne vulgaris without concomitant systemic therapy. The series included a small number of Caucasians (13 patients)…
Klimt C R, Canner P L·Clinical pharmacology and therapeutics
Long-term trials often include more than one active treatment group. These may be discontinued independently if found ineffective or possibly harmful. Certain subgroups of patients may be discovered, in the course of a clinical trial, who do not respond satisfactorily and are, therefore, excluded during the course of a…
Andrieu J M, Bayle-Weisgerber C, Boiron M, +6 more·European journal of cancer
Abstract not available
Stanish W M, Gillings D B, Koch G G·Biometrics
This paper presents an analysis of a longitudinal multi-center clinical trial with missing data. It illustrates the application, the appropriateness, and the limitations of a straightforward ratio estimation procedure for dealing with multivariate situations in which missing data occur at random and with small probabil…
Dickson R A, Leatherman K D·Acta orthopaedica Scandinavica
A pilot study of ten individuals with adolescent-onset idiopathic scoliosis demonstrated that a week of Cotrel traction and exercises did not improve curve correction obtained by the application of an elongation, derotation, flexion (EDF) cast. There was, however, a significant improvement on lateral bending correction…
Hedges A, Rose J, Leighton M, +1 more·Journal of clinical pharmacology
In a double-blind clinical trial, meptazinol (400-mg capsules) was shown to be significantly better than placebo in relieving postoperative pain in patients who had under gone total abdominal hysterectomy operations. Analgesic activity was assessed by patients rating their pain before and 1 hour after the administratio…
Levitt E A, James N M, Flavell P·The Australian and New Zealand journal of psychiatry
The study assessed the effectiveness of electrosleep therapy in the treatment of depression, anxiety, and sleep difficulties in a small, heterogenous sample of psychiatric inpatients. A double-blind format was employed, one group receiving active treatment while the other received simulated treatment. The results showe…
Baum M, Edwards M H, Magarey C J·British medical journal
From a study of the organization of a national clinical trial on the management of early cancer of the breast in women there appear to be overwhelming advantages in studying large numbers of patients. To this end centres abroad have been encouraged to join. All the evidence at present suggests that it is feasible to or…