5,000,071 papers found

The evidence base for wound healing management is lacking. This article discusses the methods of assessing evidence base and makes the plea for more research.

AIM: This meta-review examined the incidence and prevalence rates of pressure ulcers in paediatric populations, to place in context the scope of the problem in this cohort of patients. The findings provide a foundation for future research on early factors contributing to paediatric pressure ulcers, aiming to improve un…

OBJECTIVE: To compare rapid reviews (RRs) to same-topic systematic reviews (SRs) for methods, studies included, and conclusions. STUDY DESIGN AND SETTING: A retrospective comparison of studies comparing RRs and SRs by searching four scoping reviews published between 2007 and 2016. Reports were included if literature s…

Transfusion medicine has become a large and complex specialty. Although there are now systematic reviews covering many aspects of transfusion, these span a large number of clinical areas and are published across more than a hundred different medical journals, making it difficult for transfusion medicine practitioners a…

Reviews of the scientific literature are critically important for synthesizing the state of knowledge and are used extensively in teaching, clinical practice and public policy. Despite the importance of literature reviews, in veterinary science little attention has been paid to the science of research synthesis. In the…

When atrial fibrillation (AF) is present in pre-operative open heart surgeries, including coronary artery bypass grafting and valve operations, it represents an independent risk factor for cardiac events and reduced survival. Due to the complexity of the subject, especially when evaluating success rates (reversion and…

OBJECTIVE: To describe the principal role of value judgments in the analysis and synthesis of evidence as they are involved in systematic reviews, meta-analyses, and health technology assessments. METHOD: Using the tools of conceptual analysis, we characterize three main types of value judgments and propose an outline…

OBJECTIVE: We present a case of neuralgic amyotrophy (NA) diagnosed with magnetic resonance neurography (MRN) in the acute stage. METHODS: NA is an uncommon neurologic syndrome that affects mainly the brachial plexus. MRN is considered to be more sensitive than magnetic resonance imaging (MRI) for peripheral nervous s…

Diagnostic protocols for acromegaly have evolved over time reflecting the refinement of assays for the biochemical assessment of the GH-IGF-I axis and greater understanding of disease process. In February 1999, an International Consensus Conference was held in Cortina, Italy, to define the criteria for cure of acromega…

A critical evaluation of existing scientific evidence of treatment efficacy can be an important part of communicating risk and benefits of treatment options to patients during the course of clinical practice. A checklist of key methodological issues to examine when reading a research study is presented and discussed. S…

PURPOSE: From a social interactional and ecological framework, studies were reviewed that (1) compared family factors in children with epilepsy with those in children from normative groups, healthy children, children with a chronic illness, or siblings; and (2) examined the relationship between distinct family factors…

Progressive multiple sclerosis (PMS) remains a therapeutic challenge, with limited effective treatments and a high degree of uncertainty surrounding long-term efficacy and safety. In this context, the recently published Cochrane network meta-analysis by Ridley et al. (2024) represents a significant effort to synthesise…

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is widely used in lung cancer surgery, as this technique causes less pain and faster recovery than open thoracotomy. However, significant postoperative pain persists in a number of patients, often leading to increased opioid use and opioid-related adverse events i…