381,646 papers found

OBJECTIVES: This umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of the existing body of evidence. METHODS: We searched four databas…

BACKGROUND: Previous studies regarding mind-body exercise among people with breast cancer mostly focused on one type of mind-body exercise and provided conflicting results. AIMS: This paper aims to systematically synthesize the evidence hierarchy and examine the credibility of previous meta-analyses of different types…

The metabolism of estrone (E1) or estradiol-17 beta (E2) to catechols seldom has been investigated in biochemical studies related to the risk of development of human breast cancer, as a result of the extreme lability and reactivity of these hormones. A method of indirect calculation was developed in which estimated cat…

We analyzed the 2,531-patient Southwest Oncology Group extensive-stage non-small-cell lung cancer (ENSCLC) data base from 1974 to 1988 to (1) assess the interactions of host- or tumor-related prognostic factors and therapy using Cox modeling and recursive partitioning and amalgamation (RPA) to determine whether each in…

We analyzed the 2,580-patient Southwest Oncology Group (SWOG) small-cell lung cancer data base from 1976 to 1988 in order to (1) determine the prognostic value of favorable demographic and tumor-related factors and therapy programs using Cox multivariate analyses in limited- and extensive-stage disease (LD, ED), and (2…

The aim of this systematic review with pairwise and network meta-analyses was to examine the effects of different exercise types on visceral adipose tissue (VAT) in patients with prediabetes and type 2 diabetes mellitus (T2DM). A comprehensive search was conducted in PubMed, Web of Science, and Scopus using four main k…

PURPOSE: Epilepsy surgery is a safe surgical procedure, but it may be associated with cognitive changes. Estimates of the risk of decline in specific neuropsychological domains after epilepsy surgery would assist surgical decision making in clinical practice. The goal of this study was to conduct a systematic review to…

OBJECTIVES: This study aimed to determine the proportion of statistically nonsignificant meta-analyses that provide evidence favoring the null hypothesis of no difference, evidence favoring the alternative hypothesis, or inconclusive findings using likelihood ratios. STUDY DESIGN AND SETTING: In this meta-epidemiologi…

INTRODUCTION: Meta-analyses on breast cancer determinants in low- and middle-income countries (LMICs), including upper-middle-income countries (UMICs), often produce fragmented, context-specific findings. This umbrella review provides a consolidated synthesis to identify consistent risk factors and strengthen the evide…

There is no comprehensive umbrella review exploring the connection between schizophrenia and various health outcomes. Therefore, we aimed to systematically review existing meta-analyses about schizophrenia-associated comorbid health outcomes and validate the evidence levels. We performed an umbrella review of meta-anal…

The risk of pelvic inflammatory disease (PID) associated with use of an intrauterine device (IUD) has been an important concern that has dominated decisions on its use throughout the world, especially in the USA. Early research that suggested such an association led to both a dramatic decline in use of the method and i…

BACKGROUND: Resveratrol has shown health benefits like anti-obesity, antioxidant, and anti-inflammatory effects. OBJECTIVES: To resolve conflicting findings and clarify its impact, our study summarizes resveratrol supplementation’s effects and evaluates its effectiveness across populations. METHODS: We conducted…

OBJECTIVES: This study investigated the effects of different exercise interventions on intrahepatic lipid content and markers of glucose homeostasis and liver function in adults with and without nonalcoholic fatty liver disease (NAFLD). METHODS: A comprehensive search was conducted in PubMed, Scopus, Web of Science, a…

OBJECTIVE: To summarize and assess the existing evidence on the effectiveness and safety of immune checkpoint inhibitors (ICIs) treatments in patients diagnosed with hepatocellular carcinoma (HCC). DESIGN: An umbrella review encompassing current meta-analyses reporting clinical effectiveness or safety outcomes of ICIs…

OBJECTIVE: To examine and summarise evidence from meta-analyses of cohort studies that evaluated the predictive associations between baseline cardiorespiratory fitness (CRF) and health outcomes among adults. DESIGN: Overview of systematic reviews. DATA SOURCE: Five bibliographic databases were searched from January 2…

BACKGROUND: Perioperative oxygen administration has been proposed as a strategy to reduce postoperative complications. However, uncertainty exists as to which strategies are the most clinically effective. OBJECTIVES: To provide an overview on the effectiveness of perioperative oxygen therapy and formulate recommendati…

Pregnancy is rare among breastfeeding women with lactational amenorrhoea. The lactational amenorrhoea method (LAM) is the informed use of breastfeeding as a contraceptive method by a woman who is still amenorrhoeic, and who is not feeding her baby with supplements, for up to 6 months after delivery. Under these three c…

The contraceptive progestin norgestimate (NGM) has a high affinity for uterine progestin receptors and a lack of affinity for androgen receptors similar to that of natural progesterone. NGM's selectivity results in excellent efficacy, cycle control, and minimal androgenicity when it is combined with ethinyl estradiol (…

OBJECTIVES: To evaluate the influence of bias from methodological characteristics on intervention effect estimates in nutrition randomized controlled trials (RCTs) using the Cochrane Risk Of Bias 2 (RoB2) tool. METHODS: RCTs published until 2020 were selected from a representative sample of 183 nutrition meta-analyses…

BACKGROUND: This analysis summarized Cochrane reviews that assess the effects of neuraxial anesthesia on perioperative rates of death, chest infections, and myocardial infarction. METHODS: A search was performed in the Cochrane Database of Systematic Reviews on July 13, 2012. We have included all Cochrane systematic r…