391,955 papers found

The outbreak of SARS-CoV-2, which causes COVID-19, has significantly impacted the psychological and physical health of a wide range of individuals, including healthcare professionals (HCPs). This umbrella review aims provide a quantitative summary of meta-analyses that have investigated the prevalence of stress, anxiet…

BACKGROUND: This study aimed to compare the treatment responses between smokers and non-smokers in bipolar mania clinical trials. METHODS: Post-hoc analysis was conducted on data collected from three double-blind, randomised controlled trials in bipolar mania that had similar inclusion criteria. Patients were randomis…

We performed 2 metaanalyses of placebo-controlled and comparative clinical trials to examine the relative efficacy and toxicity of methotrexate (MTX), injectable gold, D-penicillamine (DP), sulfasalazine (SSZ), auranofin (AUR), and antimalarial drugs, the second-line drugs most commonly used to treat rheumatoid arthrit…

BACKGROUND: Intravascular imaging-guided percutaneous coronary intervention (PCI) reduces cardiovascular events compared with angiography-guided PCI alone. However, there is a paucity of data comparing these approaches in patients with complex coronary artery lesions and their respective subgroups. OBJECTIVES: The aim…

BACKGROUND: Nausea and vomiting of pregnancy (NVP) are common symptoms during early pregnancy that significantly impact maternal quality of life and fetal development. Given concerns about the safety of pharmacological treatments, non-pharmaceutical Chinese medical therapies (NPCT) have been new topics of great interes…

BACKGROUND: The management of metastatic prostate cancer (mPC) has shifted from a purely systemic approach to an integrated paradigm incorporating local and metastasis-directed therapies. Advances in imaging and improved characterization of the oligometastatic state have stimulated renewed interest in aggressive multim…

BACKGROUND: Total hip arthroplasty (THA) is a highly successful orthopedic procedure, with numerous meta-analyses published to optimize its outcomes. However, the reliability of their results and conclusions depends heavily on the use of appropriate statistical methods. Therefore, the aim was to test the reliability of…

OBJECTIVE: To summarize safety and tolerability data on orally administered almotriptan from premarketing clinical trials. BACKGROUND: Almotriptan is a new 5-HT1B/1D receptor agonist similar to sumatriptan in mode of action and therapeutic efficacy. In addition, the safety and tolerability profile of almotriptan has b…

BACKGROUND: Regular exercise is a first-line nonpharmacological strategy for managing metabolic syndrome (MetS), but varied exercise modalities and outcomes across studies have led to inconsistent findings that limit clinical guidance. OBJECTIVE: To synthesize up-to-date evidence on the efficacy of exercise-based inte…

BACKGROUND: Previous studies regarding mind-body exercise among people with breast cancer mostly focused on one type of mind-body exercise and provided conflicting results. AIMS: This paper aims to systematically synthesize the evidence hierarchy and examine the credibility of previous meta-analyses of different types…

Non-invasive brain stimulation (NIBS) is sometimes used alongside medication to alleviate motor symptoms in people with Parkinson's disease (PD). However, the evidence supporting NIBS's effectiveness for improving motor function in PD patients is uncertain.. This umbrella review aims to synthesize recent systematic rev…

The metabolism of estrone (E1) or estradiol-17 beta (E2) to catechols seldom has been investigated in biochemical studies related to the risk of development of human breast cancer, as a result of the extreme lability and reactivity of these hormones. A method of indirect calculation was developed in which estimated cat…

We analyzed the 2,531-patient Southwest Oncology Group extensive-stage non-small-cell lung cancer (ENSCLC) data base from 1974 to 1988 to (1) assess the interactions of host- or tumor-related prognostic factors and therapy using Cox modeling and recursive partitioning and amalgamation (RPA) to determine whether each in…

PURPOSE: Epilepsy surgery is a safe surgical procedure, but it may be associated with cognitive changes. Estimates of the risk of decline in specific neuropsychological domains after epilepsy surgery would assist surgical decision making in clinical practice. The goal of this study was to conduct a systematic review to…

OBJECTIVE: To assess the efficacy of combination therapy with insulin and sulfonylurea in the treatment of NIDDM. RESEARCH DESIGN AND METHODS: Studies published between January 1966 and January 1991 were identified through a computerized Medline search and by hand searching the bibliographies of identified articles. W…

Fifty-nine European teams have reported 919 autografts for the consolidation of acute myelocytic leukemia (AML) up to December 31, 1989. The distribution for autologous bone marrow transplantation (ABMT) was 671 in first complete remission (CR1) and 196 in CR2. Pretransplantation regimes were: total-body irradiation (T…

OBJECTIVES: This umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of the existing body of evidence. METHODS: We searched four databas…

BACKGROUND: Resveratrol has shown health benefits like anti-obesity, antioxidant, and anti-inflammatory effects. OBJECTIVES: To resolve conflicting findings and clarify its impact, our study summarizes resveratrol supplementation’s effects and evaluates its effectiveness across populations. METHODS: We conducted…

The risk of pelvic inflammatory disease (PID) associated with use of an intrauterine device (IUD) has been an important concern that has dominated decisions on its use throughout the world, especially in the USA. Early research that suggested such an association led to both a dramatic decline in use of the method and i…

We analyzed the 2,580-patient Southwest Oncology Group (SWOG) small-cell lung cancer data base from 1976 to 1988 in order to (1) determine the prognostic value of favorable demographic and tumor-related factors and therapy programs using Cox multivariate analyses in limited- and extensive-stage disease (LD, ED), and (2…