391,881 papers found

For 39 controlled studies on the analgesic effect of antidepressants, a meta-analysis was conducted to get an estimation of the effect size, and to obtain a sight on the possible modes of action and the methodology used. The mean size of the analgesic effect was 0.64. It means that the average chronic pain patient who…

BACKGROUND AND DESIGN: We previously reported a meta-analysis of all randomized clinical trials comparing 5-FU to 5-FU plus intravenous d.l. leucovorin (LV) in patients with advanced colorectal cancer. RESULTS: The meta-analysis confirmed the advantage of 5-FU/LV over 5-FU alone in terms of response rate: overall, the…

This two-part meta-analysis combined data from eight prospective randomized trials designed to compare the nutritional efficacy of early enteral (TEN) and parenteral (TPN) nutrition in high-risk surgical patients. The combined data gave sufficient patient numbers (TEN, n = 118; TPN, n = 112) to adequately address wheth…

Although it is generally agreed that prophylactic antibiotics are necessary for the prevention of postoperative wound infection, the choice of antibiotic regimen is controversial. In an attempt to determine the most effective antibiotic regimen, a meta-analysis of published clinical trials of prophylactic antibiotics f…

Developmental change in twin similarity was examined with age contrasts in a meta-analysis of twin studies from 1967 through 1985. Intraclass rs were coded from 103 papers that included data for monozygotic or dizygotic twins, or for both, on personality or intelligence variables. Analyses indicated that there was a ge…

Attempts to estimate the effects of dietary cholesterol on serum cholesterol by meta-analysis have not previously included baseline together with added dietary cholesterol in a mathematical model. Mean reported changes in serum cholesterol from 27 studies in which controlled diets were supplied by a metabolic kitchen p…

Replacement therapy with surfactant extracts in premature infants with respiratory distress syndrome has been evaluated in several clinical trials. The results of individual trials do not provide conclusive evidence that administration of a single dose of surfactant improves morbidity or mortality. Meta-analysis is a s…

OBJECTIVE: To determine whether low protein diets retard the development of end stage renal disease. DESIGN: Meta-analysis of 46 trials since 1975, from which six randomised controlled trials were selected. SETTING: Five trials in Europe and one in Australia between 1982 and 1991. SUBJECTS: 890 patients with mild to…

PURPOSE: For pediatric primary vesicoureteral reflux (VUR), there are several treatments but a ranking based on comparative efficacy and safety remains unclear. This network meta-analysis aims to rank the effectiveness and safety of multiple treatments for pediatric primary vesicoureteral reflux (VUR). The treatments e…

Whether ceftazidime monotherapy is equal in efficacy to combination regimens (Comb) for empiric treatment of febrile neutropenic patients was tested using meta-analysis. Published studies and abstracts of ceftazidime trials were identified, their quality assessed, the efficacy data abstracted and pooled, and effects of…

Studies designed to examine effects of weight reduction by dieting on total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), very-low-density-lipoprotein cholesterol (VLDL-C), and triglycerides (TGs) have reported inconsistent results. The purpose of this stud…

A meta-analysis of studies examining the interrater reliability of the standard practice of peer assessments of quality of care was conducted. Using the Medline, Health Planning and Administration, and SCISEARCH databases, the English-language literature from 1966 through 1991 was searched for studies of chance correct…

PURPOSE: Anaplastic thyroid cancer (ATC) is a highly aggressive tumour with a near 100% disease specific mortality. Despite these issues, there exists a lack of a standardised treatment regimen. We present a systematic review and the first ever network meta-analysis discussing a wide range of treatment options, namely…

BACKGROUND: Social participation is a core indicator of long-term recovery, but it significantly decreases after a stroke. Diverse single-, bi-, or multi-dimensional interventions showed differing effects on improving stroke survivors' participation. OBJECTIVES: To compare the effectiveness of current interventions ba…