5,000,071 papers found

The value of different pharmaceuticals in treating migraine is frequently based on clinical efficacy only. This article assumes a broader perspective and compares the clinical, economic, and humanistic attributes of two antimigraine medications, dihydroergotamine (DHE) and sumatriptan, based on a literature review. DHE…

PURPOSE: Although medicinal cannabis is prescribed for conditions such as pain, epilepsy, nausea and vomiting during cancer treatment, evidence about associated adverse side effects is still evolving. Because adverse events (AEs) might impact the performance of workers, it is important to consider their implications on…

OBJECTIVES: Tinnitus is a highly prevalent and challenging neurotologic condition affecting over 740 million individuals worldwide. Despite the growing number of studies, treatment approaches remain fragmented and inconsistent. This umbrella review aims to aggregate results from systematic review to comprehensiv…

AIM/OBJECTIVE: This review assessed the quality and findings of systematic reviews on AI in dentistry, categorising advancements across various specialties. METHODS: The review analyzed data from seven databases, assessed review quality with ROBIS, calculated pooled AI performance estimates, and identified research ga…

OBJECTIVES: There are two technologies for restoring individual structurally defective teeth. A direct restoration is applied chairside in one appointment, while an indirect restoration needs to be lab-produced before application. This umbrella review of previous English systematic reviews was conducted to determine if…

BACKGROUND: Seeking help for perinatal mood and anxiety disorders is crucial for women's mental health and babies' development, yet many women do not seek help for their condition and remain undiagnosed and untreated. This systematic review of systematic reviews aimed at summarizing and synthesizing findings from all s…

PURPOSE: Improvements in diagnosis and treatment mean that the long-term health of breast cancer survivors (BCS) is increasingly dictated by cardiovascular comorbidities. This is partly a consequence of exposure to cardiotoxic therapies, which result in cardiac dysfunction and decreased cardiorespiratory fitness (CRF).…

OBJECTIVE: To evaluate the relationship between birth weight and the autonomic nervous system in adulthood through a systematic review. DATA SOURCE: This is a systematic review of publications without limitation of year and language. We included studies involving the autonomic nervous system and birth weight in adults…

INTRODUCTION: Chronic venous disease is a persistent venous drainage alteration caused by valvular incompetence and/or outflow obstruction. Disease management includes a variety of treatments, whose evidence and clinical performance in the mid-long term are variable. The objective of this umbrella review was to summari…

PURPOSE: To summarize the findings and evaluate the role of vibratory therapy in the rehabilitation of neurological diseases. METHODS: We systematically research PubMed, Scopus, Embase, Physiotherapy Evidence Database (PEDro), Web of Science, and Cochrane library databases from the inception until November 2020. We in…

AIMS: To recommend a list of complications of glaucoma surgery to be used in future glaucoma surgery research and reporting by exploring the spectrum of complications' names, the variety of definitions and time frames used for reporting them in glaucoma surgical trials. METHODS: Complications' names, definitions and t…

INTRODUCTION: Increasing demand for reliable evidence in patient care and its delivery has necessitated the development of several approaches for generating quality evidence. In particular, the solicitation of expert opinion has been recognised as a reliable data collection method. However, there are variations and lim…

BACKGROUND: Corruption is widespread in Nigeria's health sector but the reasons why it exists and persists are poorly understood and it is often seen as intractable. We describe a consensus building exercise in which we asked health workers and policy-makers to identify and prioritise feasible responses to corruption i…

BACKGROUND: There has been growing interest regarding the impact of telemonitoring and its ability to reduce the increasing burden of chronic diseases, including chronic cardiovascular disease (CVD), on healthcare systems. A number of randomised trials have been undertaken internationally and synthesised into various s…

BACKGROUND: To update and refine systematic literature review on the association between outpatient statins use and mortality in patients with infectious disease. MATERIALS AND METHODS: We searched articles published before September 31, 2012, on the association between statins and infectious disease-related mortality…

OBJECTIVES: Myofascial pain syndrome (MPS) and myofascial trigger points (MTrPs) are important aspects of musculoskeletal medicine, including chiropractic. The purpose of this study was to review the most commonly used treatment procedures in chiropractic for MPS and MTrPs. METHODS: The Scientific Commission of the Co…

Quality assessment of primary studies is an essential component of systematic reviews (SRs). This methodological review systematically examines the choice, format and utilization of critical appraisal (CA) tools in SRs with or without meta-analyses in the field of human genetics. We searched MEDLINE, Embase, Web of Sci…

The production of systematic reviews is increasing, but their credibility is under threat. Although systematic reviews are an important tool for policymaking, their influence can be weakened by methodological problems and poor policy relevance. Using Cochrane as an example, I address standards for systematic reviews, t…

State-of-the-art data about mechanisms of immune response against diphtheria are presented. Antitoxic and antibacterial immunity as well as factors of natural resistance are characterized. Allergic and autoimmune reactions during diphtheria and their role in the development of complications are reviewed. Literature dat…

Animal models allow us to investigate the basic mechanisms by which food intake is regulated. There are a host of neuroregulators distributed across a complex central network that control eating behavior. The opioid peptides represent one family of such regulators that have been studied extensively in animals. Using an…