42,232 papers found

PURPOSE: The purpose of this systematic review is to assess the impact of shoulder surgeon volume of common shoulder procedures on hospital/surgeon efficiency, adverse events, and hospital costs. METHODS: Four online databases (PubMed, Embase, MEDLINE, and CENTRAL) were searched for literature on the influence of surg…

PURPOSE: Lung cancer is the leading cause of cancer mortality worldwide. To improve the therapeutic outcomes, drug delivery systems, and particularly liposomes, have been widely investigated. Therefore, this review analyzed systematically the literature to inquire about the safety and efficacy of liposomal formulations…

Physical activity may benefit health by modulating oxidative stress and inflammation. However, the selection of suitable exercise-induced oxidative stress biomarkers is still challenging. This study aimed at systematically summarizing the available evidence on exercise-induced oxidative stress measured in urine and/or…

BACKGROUND: Reverse homodigital island flaps (RHIFs) are increasingly used to reconstruct traumatic fingertip injuries, but there is limited evidence on the efficacy of this technique. We performed a systematic review of the literature to establish the safety and functional outcomes of RHIF for traumatic fingertip inju…

BACKGROUND: Periodontitis is an immune-inflammatory disease that leads to the progressive destruction of bone and connective tissue in the periodontal area. The cytokine network plays a primary role in tissue homeostasis, the recruitment of immune cells to control the pathogenic impact and the regulation of osteoclasti…

Obesity is defined as an abnormal/excessive accumulation of body fat, associated with health consequences. Although overall obesity does confer a significant threat to the health of individuals, the distribution of body fat, especially abdominal/central obesity is of greater importance. For practical reasons, proxy ant…

OBJECTIVE: Electroacupuncture (EA) is used in the treatment of various diseases through the use of electrical stimulation. Reports of adverse events (AEs) associated with acupuncture are relatively consistent, but the safety of EA has been less well reported. In this systematic review, we provide a summary of the types…

OBJECTIVES: The usage of oral therapies, endothelin receptor antagonists (ERAs), phosphodiesterase type-5 (PDE-5) inhibitors and prostaglandin analogs has resulted in improved outcomes in patients with pulmonary arterial hypertension related to systemic sclerosis (SSc-PAH). However, the optimal therapeutics have not be…

BACKGROUND: Cervical cancer screening reduced cancer morbidity and mortality in developed countries. Health education interventions are expected to enhance screening and early detection. Thus, this review is aimed to see the effectiveness of the interventions in cervical cancer screening uptake. METHODS: Online databa…

PURPOSE: To analyze the available evidence in the English, German and Japanese literature on the survival and complications of natural teeth with cast copings used to retain overdentures (ROD). STUDY SELECTION: A systematic search strategy was conducted using MeSH terms and pre-defined criteria. Two groups of research…

BACKGROUND: The efficacy of particulate and non-particulate steroids in patients receiving epidural steroid injections remains unclear. OBJECTIVE: The purpose of this meta-analysis was to compare the efficacy of particulate and non-particulate steroids in patients receiving epidural injections for radicular pain over…

PURPOSE: To qualitatively investigate the microbiologic profile in peri-implantitis by systematically reviewing the published literature on peri-implant infection. MATERIALS AND METHODS: Searches of the US National Institutes of Health free digital archives of the biomedical and life sciences journal literature (PubMe…

BACKGROUND: Mild traumatic brain injury is theorized to cause widespread functional changes to the brain. Resting-state fMRI may be able to measure functional connectivity changes after traumatic brain injury, but resting-state fMRI studies are heterogeneous, using numerous techniques to study ROIs across various resti…

INTRODUCTION: Peroral extrusion of peritoneal part of Ventriculoperitoneal Shunt (VPS) catheter is an extremely rare complication following VPS implantation. AIM: To review the options available for the management of peroral extrusion of VPS catheter. MATERIALS AND METHODS: PubMed, Medline, PMC (PubMed Central), Emba…

BACKGROUND: The epidemiology of urolithiasis may vary in different geographical areas in relation to various environmental factors; therefore it is important to review the information on its prevalence and incidence in different countries of the world. The aim of this study was to conduct an updated systematic review a…

BACKGROUND: Protein S is a central regulator of coagulation as it critically participates in down-regulation of both extrinsic and intrinsic pathways of the coagulation cascade. In this review, we aim to provide an update on protein S and its anticoagulant functions as a central hemostatic regulator. METHODS: Electron…

: Ineffective erythropoiesis (IE) is a hallmark of β-thalassemia and contributes to major clinical complications, including severe anemia, extramedullary hematopoiesis, and progressive iron overload. Despite its central role in disease pathophysiology, there is no established biomarker for the reliable identifica…

Complications of tonsillectomy, such as intraoperative and post-tonsillectomy hemorrhage (PTH), are not uncommon. In children, these may lead to hypovolemic shock, airway obstruction, delayed healing, and infection, among other issues. Tranexamic acid (TXA) is one of several hemostatic agents. However, its efficacy in…

Wipe-out is defined as a sudden, unexplained, and irreversible loss of residual central vision following glaucoma surgery, typically in eyes with advanced visual field damage and severely compromised optic nerves. The purpose of this review is to critically assess the current incidence, risk factors, pathophysiological…

INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder. It is one of the most common mental disorders in youth worldwide characterized by persistent overactivity and impulsivity/inattention symptoms associated with social and academic impairment. dasotraline has been sugg…