1,557,966 papers found

The prostaglandin-synthetase inhibitors fluproquazone and mefenamic acid were evaluated for relief of severe primary and secondary IUD-induced dysmenorrhea in a controlled double-blind cross-over study in 48 patients. Relief of dysmenorrhea was good to excellent in 48.7% of the treated patients and in 22.5% of the cont…

The timely dissemination of new medical information to the practicing physician has been identified as a problem. To examine the magnitude of this problem and useful strategies for correction, we surveyed primary care physicians to determine their knowledge of the Hypertension Detection and Follow-up Program, a recent…

Twenty young adults with atopic dermatitis were allocated randomly in a clinical trial to compare the action of the H2 receptor antagonist cimetidine (Tagamet) and the H1 receptor antagonist promethazine hydrochloride (Phenergan), singly and in combination. No significant differences were found, clinically or in the la…

Albendazole was given to some men for the first time. 131 patients (43 children) received different dosages, without clinical intolerance. Biological parameters were normal. Each study was made in two parts: - determination of the good dosage, - administration in a double-blind study (except for Strongyloides Stercoral…

In a single-dose study the analgesic activity of 400 mg doxpicomine was compared with 4 and 8 mg morphine administered intramuscularly. Our subjects wee 43 men with moderate or severe postsurgical pain on the first postoperative day. Results of a double-blind trial indicate the analgesic activity of 400 mg intramuscula…

A clinical study with a new anti-aggregant preparation; N-2-(p-chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104), is shown in this paper. A double blind study, was carried out comparing its effects with those of a well known antiaggregant agent, dipyridamole. No clinical nor analytical side effect…

Thirty-four children with upper or lower respiratory tract infections were randomly allocated to receive either a twice daily or four times daily dose of 50 mg amoxycillin/kg body-weight/day. Mean duration of therapy was identical in both groups. Peak and trough antibiotic concentrations were determined. Eradication of…

Two methods of assessing adverse drug effects-an open-ended question versus a checklist-were compared in a clinical study involving 515 patients being treated with bacampicillin for gonorrhea. Results indicate that adverse reactions are reported more frequently if a checklist is used. However, it was also observed that…

A total of 50 patients with moderately severe acne was treated with either 3%, 5% or 10% benzoyl peroxide gel for 4 weeks. Forty-eight patients maintained the treatment for the whole trial period while in 2 cases treatment has to be discontinued because of severe irritation of the treated skin areas. In all the remaini…

One hundred and nine male patients took part in a randomized trial of elective suprapubic or urethral catheterization in retention of urine. The self-retaining trocar suprapubic catheter proved safe and reliable in trained hands and its use was associated with a low incidence of side effects. The suprapubic catheter wh…

Nalbuphine (EN2234A) is an agonist-antagonist analgesic. It is structurally related to the narcotic analgesic oxymorphone and to the narcotic antagonist naloxone. A double blind study was carried out in 400 children in ASA classification I, ranging from 10 months to 14 years of age, to compare nalbuphine, pentazocine a…

In a randomized double-blind study involving 64 patients with impaired nasal breathing, a comparison was made of a single dose each of Farial and xylometazoline-containing nose drops with respect to effectiveness and tolerance. The assessment of the anterior rhinomanometric measurements, which were carried out on 64 pa…

Two new contrast media, Amipaque (metrizamide, Nyegaard & Co A/S, Oslo) and Hexabrix (ioxaglic acid, Laboratoire Guerbet, Paris) were compared in a double blind study in patients with arterial insufficiency in the legs. The incidence of subjective adverse effects (pain and sensation of heat) was low and similar with bo…

In a double-blind trial according to a switchback design with 4 periods of one week each a comparison was made between the effects of piracetam and a placebo. In 22 patients with vertigo of central origin (posttraumatic, psychogenic, ecileptogenic and hypertensive vertigo were excluded) piracetam was found to significa…

The clinical effects of a bronchodilator, terbutaline sulphate, were compared after administration in the beginning of the inhalation by means of a standard inhaler and administration by actuating 2 seconds before starting the inhalation by means of an inhaler furnished with a 32 X 100 mm tube. No differences could be…

Pirbuterol and salbutamol capsules were compared in a multi-centre, double-blind, crossover study. Pirbuterol 10 mg four times daily and salbutamol 4 mg four times daily produced a similar increase in peak expiratory flow rate, matched by the patients' subjective appreciation of decreased beathlessness. Both drugs prod…

Motor performance of children born to mothers living in an iodine-deficient region was assessed. The mothers were participants in a controlled trial of intramuscular iodised oil in the prevention of endemic cretinism carried out in the Western Highlands of Papua New Guinea. Mothers received either iodised oil or placeb…

The bronchodilator efficacy of oral carbuterol in the dose of 2 mg or 3 mg was compared with that of 4 mg salbutamol in a double-blind, crossover trial in 21 patients with bronchial asthma. Carbuterol 3 mg was found to be a more effective bronchodilator than salbutamol 4 mg. Both the drugs in these doses produced mild…