2,694 papers found

Conventional colectomy, and the Japanese Society for Cancer of the Colon and Rectum (JSCCR) D2 Lymphadenectomy (LND2), are currently considered standard of care for surgical management of colon cancer. Colectomy with complete mesocolic excision (CME) and JSCCR D3 Lymphadenectomy (LND3) are more radical alternative appr…

BACKGROUND: Abandonment of therapy is a significant cause of paediatric cancer treatment failure in low- to middle-income countries (LMIC), but its impact has been underestimated. We performed a meta-analysis to determine the magnitude of abandonment in paediatric leukaemia in LMIC and sought to identify patient-, cent…

BACKGROUND: The achievement of low density lipoprotein cholesterol (LDL-C) target levels, as recommended by the evidence-based international guidelines, represents the crucial prerequisite for maximal cardiovascular risk reduction in patients with dyslipidemia. OBJECTIVES: The efficacy of 3-hydroxy-3-methylglutaryl-co…

OBJECTIVE: The accelerative effect of EMLA (eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) in the wound healing process is known. We hypothesised that post-operative peritoneal adhesions may be reduced with intra-peritoneal EMLA administration in a model of bacterial peritonitis. STUDY DESIGN: Bacterial perit…

BACKGROUND: Large language models (LLMs) offer promise for systematic review data extraction, but performance in complex multidisciplinary domains and utility for clinical statement generation remain insufficiently described. OBJECTIVES: To evaluate Google NotebookLM for AI-assisted data extraction and RAND/UCLA conse…

Emerging evidence suggests that maternal food intake and nutritional status may modify the relationship between environmental toxicants and early-life health risks, potentially mitigating their adverse effects. However, the interplay between nutritional status, environmental exposures, and health outcomes remains poorl…

Adolescent idiopathic scoliosis is a common spinal orthopedic condition that is associated with a high prevalence of vitamin D deficiency. Vitamin D is known to affect bone health, and we conducted a systematic review to assess the impact of vitamin D deficiency on patients diagnosed with adolescent idiopathic scoliosi…

INTRODUCTION: Diaphragm dysfunction is prevalent across various patient populations, requiring precise structural and functional assessment. Ultrasound, being bedside-accessible and radiation-free, has gained relevance for evaluating the diaphragm and other respiratory muscle. Recent advancements have introduced novel…

Progress towards a much-needed malaria vaccine has accelerated in recent years. The most significant recent event was the independent licensure of the first two subunit vaccines against malaria, RTS,S/AS01 (Mosquirix) from GSK and R21/Matrix-M from the Serum Institute of India, which received full World Health Organisa…

BACKGROUND: Pharmaceutical care is currently being implemented in Polish community pharmacies, but remains unsupported by state funding, limiting its widespread adoption. In Spain pharmacists there provide a wide range of pharmaceutical care services. OBJECTIVE: The aim of the work is to understand how other countries…

PURPOSE: To identify and describe language assessment protocols from the perspective of ABA used in speech-language therapy. RESEARCH STRATEGIES: The question that guided the study was: What are the ABA-based language assessment protocols currently used in speech therapy? For the electronic search of articles, the dat…

Body composition assessment by ultrasonography is a vivid research field. Ultrasound (US) can be used to quantify subcutaneous and visceral fat, to evaluate the quantity and quality of skeletal muscle, and to infer intracellular fat content. This scoping review aimed to summarize recent advancements in subcutaneous fat…

Applications of radiomics for clinical management of medulloblastomas are expanding. This systematic review aims to aggregate and overview the current role of radiomics in the diagnosis, subtyping, and prognostication of medulloblastomas. The present systematic review was performed in accordance with the Preferred Repo…

INTRODUCTION: An unusual association between thyroid dysfunction and autoimmune encephalitis (AE) was noticed when patients presented with low free triiodothyronine (fT3) levels and antithyroid antibodies. We conducted a meta-analysis to investigate whether thyroid dysfunction, that is, lower fT3 levels are associated…

Limb fractures are a common cause of pediatric hospital admissions and surgeries, with a significant prevalence in the United Kingdom across all injury categories. Among psychiatric conditions in children, attention deficit hyperactivity disorder (ADHD) stands out as frequently associated with fractures, particularly t…

OBJECTIVES: To improve health and safety outcomes at mass gathering events (MGEs) for young attendees, it is essential to understand the psychosocial factors that may influence behaviour so that the implementation of support strategies before, during and after MGEs can be developed to enhance outcomes. This review iden…

BACKGROUND: Welfare legal problems and inadequate access to support services follow both the socioeconomic and the health inequalities gradients. Health Justice Partnership (HJP) is an international practitioner-led movement which brings together legal and healthcare professionals to address the root causes of ill heal…

BACKGROUND: Open access publishing in plastic surgery has rapidly gained traction in the past decade. This study investigated the digital landscape of plastic surgery open access publishing. METHODS: This was a cross-sectional bibliometric investigation of plastic surgery-focused journals. Three publication models wer…

Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by the appearance of erythematous plaques, covered by white scales, occasionally pruritogenic, and distributed mainly on the extensor areas. Oxidative stress is defined as an imbalance or a transient or chronic increase in the levels of free…

OBJECTIVE: Synovial sarcoma is the most common soft tissue sarcomas among childhood and adolescents, accounting for 8-10% of all soft tissue sarcoma. Synovial sarcoma is considered a relatively chemosensitive tumor compared with other soft tissue sarcomas. However, the role of perioperative chemotherapy in synovial sar…