2,589 papers found

PURPOSE: The shape and position of the hemoglobin-oxygen dissociation curve (ODC) is of critical importance in medicine, as it determines the uptake of Oin the lungs and the delivery of Oto the tissues. Numerous reports have identified affinity-modulating effects of drugs in humans. Such effects may be relevant to cond…

BACKGROUND: Epithelial ovarian cancer kills about 1700 in the UK each year. Ten to fifteen percent of all cases are diagnosed early when there is still a good chance of cure. The treatment of early stage disease involves surgery to remove disease often followed by chemotherapy. The largest clinical trials of this adjuv…

OBJECTIVES: Artificial intelligence (AI) has tremendous potential to help radiologists in daily clinical routine. However, a seamless, standardized, and time-efficient way of integrating AI into the radiology workflow is often lacking. This constrains the full potential of this technology. To address this, we developed…

The aim of this study was to compare the fit of all-ceramic restorations on natural teeth fabricated through a direct digital workflow or an indirect digital workflow. An electronic search of publications was established from three electronic databases: Cochrane, PubMed and Web of Science. The search strategy used a co…

BACKGROUND: Full syntactic parsing of clinical text as a part of clinical natural language processing (NLP) is critical for a wide range of applications. Several robust syntactic parsers are publicly available to produce linguistic representations for sentences. However, these existing parsers are mostly trained on gen…

Physicians need to understand, evaluate and address hemodynamics in every patient and even more importantly in patients that are critically ill. Being able to determine and interpret central venous pressure is one of the most useful bedside evaluation skills, even in the 21st century (Fig. 3). Full Text (Free, PDF) www…

BACKGROUND: Systematic reviews are complex and involve time-consuming, deep research in the academic literature to search, extract data, assess their quality and report the results. Digital tools and software have been developed to simplify different phases of this process but some of these are not free to use. Microso…

BACKGROUND: With the advent of direct acting antivirals, the World Health Organisation proposed eliminating Hepatitis C as a public health threat by 2030. To achieve this, countries need to diagnose, engage in care and treat their undiagnosed populations. This will require sensitisation campaigns. However previous medi…

Renal function (RFn) after orthotopic bladder substitution (OBS) is a critical point to be assessed. We performed a systematic review of MEDLINE for full length peer reviewed English articles from the year 2000 till January 2013. We included only original articles and excluded reviews, editorials and replies and abstra…

BACKGROUND: Genotype-phenotype maps provide a meaningful filtration of sequence space and RNA secondary structures are particular such phenotypes. Compatible sequences, which satisfy the base-pairing constraints of a given RNA structure, play an important role in the context of neutral evolution. Sequences that are sim…

AIM: To assess how the various methods of intracanal reinforcement (short root canal posts) performed in their clinical and radiographic outcomes for restoring grossly broken down primary anterior teeth after pulpectomy for 1 year or longer follow-up period. MATERIALS AND METHODS: Literature search of electronic datab…

The limitation of artificial intelligence (AI) large language models to diagnose diseases from the perspective of patient safety remains underexplored and potential challenges, such as diagnostic errors and legal challenges, need to be addressed. To demonstrate the limitations of AI, we used ChatGPT-3.5 developed by Op…

OBJECTIVE: To asses the complex anti-reflux treatment of pure venous ulcers on all levels of venous system. PATIENTS: In the last 20 years the authors treated 793 patients with venous ulceration and compared the therapeutic results of 4 groups of patients treated either surgically (Linton+v.v. surgery) or with sclerot…

Which population factors have predisposed people to disregard government safety guidelines during the COVID-19 pandemic and what justifications do they give for this non-compliance? To address these questions, we analyse fixed-choice and free-text responses to survey questions about compliance and government handling o…

BACKGROUND: Dissecting free tissue flaps can be challenging and time-consuming. Imaging technologies are typically used to assist with preoperative planning. However, conventional methods have limitations that could potentially be overcome by extended reality technologies. This systematic review aimed to evaluate the c…

The aim of the article is to explain in more detail the biomechanical methods used in determining bone quality as well as to describe basic characteristic bone qualities resulting from the application of these methods. Mechanical properties of biomaterials are characterised by stress-strain curves, produced on the basi…

BACKGROUND: Children in lower middle-income countries (LMICs) are more at risk of dying, than those in High Income Countries (HICs), due to highly prevalent deadly yet preventable childhood infections. Alongside concerns about the incidence of these infections, there has been a renewed interest in involving community h…

CONTEXT: Celiac disease (CD) is defined as a permanent intolerance to ingested gluten. The intolerance to gluten results in immune-mediated damage of small intestine mucosa manifested by villous atrophy and crypt hyperplasia. These abnormalities resolve with initiationa gluten-free diet. EVIDENCE ACQUISITION: PubMed,…

Automatic International Classification of Diseases (ICD) coding aims to assign multiple ICD codes to a medical note with an average of 3,000+ tokens. This task is challenging due to the high-dimensional space of multi-label assignment (155,000+ ICD code candidates) and the long-tail challenge - Many ICD codes are infre…

Wandering spleen is characterized by ectopic localization of spleen owing to the lack or weakening of the major splenic ligaments. In present study, two cases with torsion of wandering spleen were reported. The first case was a 30-year-old female who was admitted to emergency department with acute abdominal pain and vo…