381,523 papers found

BACKGROUND AND DESIGN: We previously reported a meta-analysis of all randomized clinical trials comparing 5-FU to 5-FU plus intravenous d.l. leucovorin (LV) in patients with advanced colorectal cancer. RESULTS: The meta-analysis confirmed the advantage of 5-FU/LV over 5-FU alone in terms of response rate: overall, the…

Meta-analysis was used to establish the efficacy of lithium in acute treatment and prophylaxis of depressive illness from existing published clinical trials. Effect sizes were measured by the odds ratio using the Mantel-Haenszel method and the Pearson product-moment correlation coefficient. Some benefit from lithium, c…

This two-part meta-analysis combined data from eight prospective randomized trials designed to compare the nutritional efficacy of early enteral (TEN) and parenteral (TPN) nutrition in high-risk surgical patients. The combined data gave sufficient patient numbers (TEN, n = 118; TPN, n = 112) to adequately address wheth…

A meta-analysis was conducted on 73 studies of social skills training in four adult psychiatric populations: developmentally disabled, psychotic, nonpsychotic, and legal offenders. Findings from this analysis showed that patients participating in social skills training programs broadened their repertoire of skills, con…

BACKGROUND: Direct oral anticoagulants (DOACs) are increasingly preferred over vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), including valvular (VAF) and non-valvular (NVAF). This network meta-analysis aimed to evaluate and compare the efficacy and safety of different DOACs versus VKAs…

Left ventricular hypertrophy (LVH) is an independent risk indicator of cardiovascular disease. Obtaining reversal of hypertension-induced cardiac hypertrophy seems to be a desirable objective of antihypertensive treatment. A total of 2,357 patients were included in a meta-analysis on the effect of antihypertensive phar…

PURPOSE: Anaplastic thyroid cancer (ATC) is a highly aggressive tumour with a near 100% disease specific mortality. Despite these issues, there exists a lack of a standardised treatment regimen. We present a systematic review and the first ever network meta-analysis discussing a wide range of treatment options, namely…

ObjectiveThis study aimed to compare the effects of different dual-task training modalities on walking and balance in stroke patients using network meta-analysis.Data sourcesRandomized controlled trials were searched in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Chine…

The value of antibiotic prophylaxis in abdominal hysterectomy was reviewed by meta-analysis. Two independent literature searches (1986-1988) yielded 150 relevant papers, however, only 17 (11.3%) papers met our inclusion criteria. The selected papers described prospective, randomized, blinded, placebo-controlled studies…

A meta-analysis of 205 studies involving 23,702 Ss was conducted to determine whether there are sex differences in self-disclosure. Across these studies, women disclosed slightly more than men (d = .18). This effect size was not homogeneous across studies. Several moderator variables were found. Sex of target and the i…

Hussey (in press) recently conducted a detailed critical reanalysis of Vahey, Nicholson and Barnes-Holmes' (2015) meta-analysis. Its stated purpose was to (a) examine the extent to which Vahey et al.'s (2015) meta-analysis contains errors; and (b) to test how computationally reproducible it is by current standards of b…

This paper reports a follow-up of previous meta-analysis research conducted by the author on the effects of diabetes patient education on patient outcomes. An expanded sample of studies and psychological outcome variables were added to the previously studied variables of patient knowledge, self-care behaviors (complian…

For 39 controlled studies on the analgesic effect of antidepressants, a meta-analysis was conducted to get an estimation of the effect size, and to obtain a sight on the possible modes of action and the methodology used. The mean size of the analgesic effect was 0.64. It means that the average chronic pain patient who…

The present work summarizes the currently available published studies on lung cancer and occupational acrylonitrile exposure. Meta-analytic methods were used to estimate the overall risk. To adjust for the healthy worker effect, rate ratio estimates based on regression analyses and ratios of standard mortality ratios w…

We reviewed the literature on fetal pleural effusion to identify prognostic indicators related to outcome. Data on 124 cases from 38 reports were collected and analyzed using chi 2 statistical analysis and stepwise multiple logistic regression. Termination of pregnancy occurred in ten cases, spontaneous resolution occu…

An extension to the genome screen meta-analysis (GSMA) method is proposed that allows results from candidate region studies to be included in a meta-analysis of genome-wide search results. Quantitative linkage analyses for susceptibility loci linked to total IgE were performed for data from three genome-wide searches a…