2,694 papers found

In recent years, increased longevity, poor dietary habits, and the rising prevalence of metabolic syndrome and hypertension have increased the prevalence of gout. Gout significantly increases direct and indirect costs and reduces the quality of life. Allopurinol and febuxostat are the most commonly used drugs for reduc…

OBJECTIVE: To identify the critical pathway taken by women facing domestic violence in the world in their search for help. METHOD: An integrative review was performed. LILACS, MEDLINE/ PubMed, EMBASE, Scopus, and Web of Science databases were searched until year 2017. The following were inclusion criteria: full text a…

Head and neck cancer remains a leading cause of death worldwide. Most common available treatment methods which include surgery, radiotherapy, and chemotherapy are associated with numerous side effects. MicroRNA therapeutics is an emerging form of gene therapy with potential for use in treatment of head and neck cancer.…

OBJECTIVE: To describe parents' perspectives and likelihood of speaking up about safety concerns in the NICU and identify barriers and facilitators to parents speaking up. DESIGN: Exploratory, qualitatively driven, mixed-methods design. SETTING: A 50-bed U.S. academic medical center, open-bay NICU. PARTICIPANTS: For…

OBJECTIVE: The aim of this review was to systematically examine the evidence for an association between measures of obesity [weight and body mass index (BMI)] and body composition (fat mass and fat-free mass) and patellar cartilage, assessed using magnetic resonance imaging. METHODS: Three electronic databases (MEDLIN…

We are rapidly approaching the point where we have sequenced millions of human genomes. There is a pressing need for new data structures to store raw sequencing data and efficient algorithms for population scale analysis. Current reference-based data formats do not fully exploit the redundancy in population sequencing…

The European Statements of Hospital Pharmacy are a set of hospital pharmacy practice standards published by the European Association of Hospital Pharmacists (EAHP) for European health systems to ensure safe, effective and optimal use of medicines in collaboration with multidisciplinary teams. Keele University was commi…

Obesity is a global epidemic affecting over 1.5 billion people and is one of the risk factors for several diseases such as type 2 diabetes mellitus and hypertension. We have constructed a comprehensive map of the molecules reported to be implicated in obesity. A deep curation strategy was complemented by a novel semi-a…

OBJECTIVES: To systematically review the literature concerning techniques of closure of endoscopically created skull base defects based on site of skull base defect and flow rate of cerebrospinal fluid (CSF). DATA SOURCES: PubMed, SCOPUS, and Cochrane databases. REVIEW METHODS: A comprehensive systematic literature r…

Since the publication of the Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG07), diagnostic criteria and severity assessment criteria for acute cholangitis have been presented and extensively used as the primary standard all over the world. However, it has been found that there are crucia…

Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) is a useful diagnostic tool for the staging of patients with multiple myeloma (MM). The aim of this study is to perform a systematic review of the usefulness of FDG-PET or PET/CT in monitoring response to treatment in patients with MM. A comprehensiv…

BACKGROUND: The aim of this study was to define treatment modalities in tubo-ovarian abscesses (TOA) using a scoring system. As there is no scoring system for TAO there is still a controversy on the management. In our opinion, as there is no evidence based TAO management strategy, a scoring system is needed in the mana…

BACKGROUND: Oral anticoagulant therapy is recommended for patients with pulmonary arterial hypertension (PAH). The rationale for the use of anticoagulant treatment is based on thrombophylic predisposition in PAH and improvement of survival in patients treated with anticoagulation. However, the target INR value has not…

OBJECTIVES: To propose a full-scenario framework for edge-side quantization deployment and multi-modal collaborative diagnosis and treatment based on the prior high-precision algorithm YOLOv11-TDSP. METHODS: A data-aware post-training quantization (PTQ) mechanism based on Kullback-Leibler divergence was constructed. T…

OBJECTIVE: To describe the implementation, scale, and stakeholder experience of a statewide clinic-to-clinic pediatric subspecialty telemedicine program improving access to care for children in rural and underserved communities. METHODS: A hub-and-spoke telemedicine network was developed linking pediatric subspecialis…

OBJECTIVE: Primary hyperparathyroidism (PHPT) has varied presentations whose successful surgical management demands integration of the expanding literature within a comprehensive decision-making framework. Our objective is to compare the workup and management of variant (i.e., normocalcemic hyperparathyroidism (NCPHPT)…

Veneers should be bonded with a resin cement that will undergo minimal discoloration over time. This narrative review was conducted to compare the shade stability of lithium disilicate veneers seated with light-curing (LC) vs dual-curing (DC) resin cement. The PubMed database was searched for in vitro and in vivo studi…

PURPOSE: To synthesise evidence on barriers to cataract surgery uptake in Africa across patient, community, and health system levels, describe regional variation, and identify evidence gaps. METHODS: We conducted a systematic review of multiple databases for studies published from January 2000 to March 2025. Searches…

BACKGROUND AND OBJECTIVES: Primary vesicoureteral reflux (VUR) is a common pediatric urological disorder that can lead to significant renal morbidity if undetected or improperly managed. Ultrasound (US) plays a pivotal role in its assessment, providing a radiation-free tool to prenatal assessment, diagnosis, treatment,…

OBJECTIVE: Due to the boom in the use of certain psychedelics in different neuropsychiatric conditions, the objective was to synthesize the available information on the use of psilocybin (a psychedelic) in the population with autism spectrum disorder (ASD; a developmental neuropsychiatric condition). METHODS: Scoping…