44,680 papers found

INTRODUCTION: Cerebral cavernous malformation (CCM) is a type of cerebrovascular abnormality in the central nervous system linked to both germline and somatic genetic mutations. Recent preclinical and clinical studies have shown that various drugs can effectively reduce the burden of CCM lesions. Despite significant pr…

Apical periodontitis is an inflammation and destruction of the periradicular tissues due to various insults to the pulp in the form of infection, trauma, and faulty dental procedures. Conditions regarding this are treated employing root canal therapy. Recent innovations show that copper calcium hydroxide nanoparticles…

BACKGROUND: Although intravenous dexamethasone prolongs the duration of analgesia for peripheral nerve blocks (PNB), the optimal dose of dexamethasone is not yet determined. This protocol aims to compare the analgesic effects of different doses of intravenous dexamethasone on PNB. METHODS: We will search PubMed, EMBAS…

The present paper reviewed the ocular complications resulting from the use of traditional eye medicine in Central Saudi Arabia. We performed a literature search of the PubMed database using the keywords "traditional medicine," "herbal medicine," "ocular injuries," and "visual impairments," covering all years available…

BACKGROUND: Lumbar disc herniation, which affects the life quality of patients and the social security system adversely, is one of the common spinal diseases. Massage is used as an alternative therapy. Currently, there are no relevant articles for systematic review. METHODS: We will search the randomized controlled tr…

AIM: Because the use of non-steroidal anti-inflammatory drugs and opioids has several restrictions, this review evaluates the efficacy and safety of acetaminophen and caffeine for the management of dental pain. METHODS: A search of the literature was carried out looking for randomized controlled trials on the use of a…

OBJECTIVE: In this study, we aimed to compare the minimally invasive surgery (MIS) instrumented fusion ± decompression versus conventional open surgery (COS) instrumented fusion ± decompression for the treatment of spinal metastases. METHODS: We performed a systematic literature search through PubMed, Scopus…

BACKGROUND: Anorexia nervosa (AN) is a severe eating disorder, recognized by a relentless pursuit for thinness and extreme low body weight. The disorder is often accompanied by comorbid disorders such as anxiety and depression, and altered neuropsychological function in terms of poor set-shifting and reduced central co…

BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease increasingly linked to neuroinflammation, and a heightened response of nociceptive neurons called central sensitisation, leading to persistent pain and functional decline. Neuroinflammation, along with dysfunction in serotonergic and noradrenergic pathways…

OBJECTIVE: The purpose of this study was to assess the effects of adenotonsillectomy (A&T) on reducing central sleep apnea (CSA) in children and adolescents with obstructive sleep apnea (OSA). METHODS: A review of the PubMed database was conducted. Two researchers independently reviewed the articles from the literatur…

Chronic malnutrition is a major public health concern that is the focus of a large body of scientific research. However, there is no synthesis of knowledge about the factors associated with this disease in West and Central Africa, where its prevalence is particularly high. We conducted a systematic search for scientifi…

BACKGROUND: The effect of balanced crystalloids compared with that of saline in critically ill patients overall and in specific subgroups is unclear. We aimed to assess whether use of balanced solutions, compared with 0·9% sodium chloride (saline), decreased in-hospital mortality in adult patients in intensive car…

OBJECTIVES: To map community-based health-promotion strategies used to improve cervical cancer screening uptake and to identify intervention components, delivery models, equity targets and implementation gaps. STUDY DESIGN: Scoping review. METHODS: The review followed PRISMA-ScR and JBI population-concept-context gui…

BACKGROUND: Non-surgical management of primary pituitary abscesses is usually reserved for patients considered high-risk or unsuitable surgical candidates. Surgical drainage followed by long-term intravenous antibiotics is the current mainstay in the reviewed literature. However, surgical management frequently fails to…

Mind Sound Resonance Technique (MSRT) is a structured yogic intervention that uses specific sound vibrations and meditative awareness to promote psychological well-being. Increasingly applied in clinical and wellness contexts, MSRT is being explored for its potential benefits in reducing anxiety, improving sleep qualit…

BACKGROUND: Cancer is the second leading cause of death globally. More millions new cancer cases are diagnosed, and millions persons died due to cancer each year. There are different attitudes on disclosure of diagnosis to the patients with cancer. The current systematic reviews are qualitative, and indicate that there…

OBJECTIVE: O(6)-methylguanine DNA methyl-transferase gene (MGMT) is a central DNA repair mechanism with a significant role in removing DNA damage caused by alkylating agents and inhibiting human oncogenesis. Two single polymorphisms in the MGMT gene, Leu84Phe and Ile143Val, have been reported to affect DNA repair capab…

This systematic review assessed the current literature regarding the analgesic treatment of central neuropathic pain (CNP) in central nervous system (CNS) conditions, such as spinal cord injuries, multiple sclerosis, post-stroke disorders, and Parkinson's disease. The aim of this systematic review was to compare the cu…

INTRODUCTION: Neural mobilization (NM) is a physiotherapy technique involving the passive mobilization of limb nerve structures with the aim to attempt to restore normal movement and structural properties. In recent years, human studies have shown pain relief in various neuropathic diseases and other pathologies as a r…

Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions. Photobiomodulation can promote neurogenesis and elicit anti-apoptotic, anti-inflammatory and antioxidative responses. Its therapeutic effects have been dem…