2,589 papers found

BACKGROUND: Restoring normal morphology and function after craniofacial fractures remains a clinical challenge. Tissue engineering, particularly through cell-free approaches using secretome (soluble proteins and extracellular vesicles), has emerged as a promising strategy for enhancing bone regeneration. This study aim…

BACKGROUND AND OBJECTIVE: Thymic epithelial tumors, comprising thymoma and thymic carcinoma, are rare and heterogeneous neoplasms for which high-level evidence is limited. Radiotherapy is integral across the disease continuum-from postoperative settings to definitive therapy for unresectable tumors and oligometastatic/…

BACKGROUND: The latissimus dorsi (LD) flap is among the most adaptable and extensively employed techniques in reconstructive surgery, providing a dependable solution for addressing a wide range of defects. Although traditionally employed for soft-tissue coverage, its indications have progressively expanded to include c…

BACKGROUND: Misfit at the implant-prosthesis interface arises from small errors that occur during impression-taking, cast fabrication and milling. Implant verification jigs (IVJs) have been described as a quality-control device in fixed implant prosthodontics, yet protocols and indications are inconsistently described…

INTRODUCTION: First aid providers may encounter life-threatening conditions requiring treatment with medications. Given that resuscitation medications in first aid kits may be administered infrequently, first aid providers may face situations where only expired medications are available. OBJECTIVE: This systematic sea…

Obesity is a global health issue characterized by an abnormal or excessive accumulation of body fat, defined as a body mass index (BMI) that exceeds 30 kg/m². Many antiobesity drugs, such as orlistat and quercetin, are often limited by poor solubility and bioavailability. These physicochemical limitations can lead…

Postmortem interval (PMI) estimation is a challenge of utmost importance in forensic daily practice. Traditional methods face limitations in accuracy and reliability, particularly for advanced decomposition stages. Recent advances in "omics" sciences, providing a holistic view of postmortem biochemical changes, offer p…

This Umbrella Review aims to gather high-quality evidence on urolithiasis outcomes and complications, comparing extracorporeal shockwave lithotripsy (ESWL), ureteroscopic lithotripsy (URSL), and retrograde intrarenal surgery (RIRS). We incorporated systematic reviews, some containing meta-analyses, into two separate re…

BACKGROUND: This study aimed to evaluate the current status of ophthalmology residency training in Switzerland and provide insights for enhancing training programs. MATERIALS AND METHODS: The survey covered demographic data such as gender, age, workplace, and year of residency, as well as working conditions, current p…

PURPOSE: Neurosurgery training in the UK has undergone significant changes over the past few years, including the new competency-based curriculum and a reduction of elective operating due to the pandemic. We conducted a comprehensive survey to assess UK neurosurgical trainees' experiences and perceptions to develop tar…

BACKGROUND: Free open access medical education (FOAM) resources have become increasingly popular in graduate medical education. Despite their accessibility, the assessment of FOAM resources' quality is challenging due to their decentralized nature and the diverse qualifications of their authors and distribution platfor…

Polycystic ovary syndrome (PCOS) is one of the most pressing problems in endocrine gynecology. The main signs of the disease are hyperandrogenism, menstrual and/or ovulatory dysfunction, and polycystic ovarian structure according to ultrasound. Women with PCOS are at risk for developing metabolic syndrome, type 2 diabe…

INTRODUCTION: In recent years, eye-tracking has been proposed as a promising tool to identify potential biomarkers for mental disorders, including major depression. We will conduct an updated systematic review and meta-analysis on eye-tracking research in adults with major depressive disorder or other clinically diagno…

Collective meal contexts such as restaurants, cafeterias and canteens can help accelerate transitions to healthier and more sustainable diets. However, evidence from intervention studies on these contexts lacks integration. This scoping review aimed to map determinants of dietary change in collective meal contexts acro…

OBJECTIVES: To describe the current state of the art regarding technological advances in full-automatic tooth segmentation approaches from 3D cone-beam computed tomography (CBCT) images. MATERIALS AND METHODS: In March 2023, a search strategy without a timeline setting was carried out through a combination of MeSH ter…

INTRODUCTION: Despite policies aiming at universal health coverage by ensuring availability and accessibility of general practitioners (GPs), medically underserved areas are still present in Europe. This systematic review aims to summarize and compare literature on interventions and their potential effectiveness of GP…

INTRODUCTION: The electronic collection of patient data is used for a large variety of conditions. The boundaries of its use in initial diagnostics and the extent to which it can replace specialist contact, however, remain vague. Our newly developed virtual diagnostic process for common sleep disorders involves digital…

AIM: The study was designed to evaluate the existing evidence on the failure rates of post-endodontic restorations retained with and without post in endodontically treated teeth (ETT). SETTINGS AND DESIGN: Preferred Reporting Items for Systematic Reviews and Meta-Analyses- Protocol (PRISMA-P) guidelines were used to f…

The ongoing coronavirus disease-2019 (COVID-19) pandemic can be acknowledged as one of the most significant public health emergencies the world has encountered in the last few decades. The purpose of the current review is to understand the significance of contact tracing and explore the pros and cons of digital contact…

BACKGROUND: Recently, we have observed an increasing focus on myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) patients. MINOCA incidence is estimated to be within the range of 5-15% of all MI cases. Unfortunately, MINOCA relates to various conditions that are not rarely hard to identify, incl…