11,355,744 papers found

AE90015 is a highly specific and effective negative allosteric modulator (NAM) for the human mGlu5 receptor, showing significant promise for treating Parkinson's disease. An in vivo rat oral dose study was conducted on AE90015, which involved the collection of urine and bile samples over a 24 h period. At the study's e…

BACKGROUND: The present study aimed to analyze IL-40, IL-1β, and MMP-8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters. MATERIALS AND METHODS: We collected saliva samples from 120 systemically he…

PURPOSE: The purpose of the present study was to identify the expression of estrogen and progesterone receptor mRNA and of estrogen and progesterone receptor protein in the conjunctiva of healthy women. METHODS: Specimens of conjunctival tissue of 10 premenopausal women (age range, 13-38 years) were obtained during op…

The present study introduces a highly sensitive bimetallic SPR biosensor based on metal nitride for efficient urine glucose detection. Using a BK-7 prism, Au (25 nm), Ag (25nm), AlN (15 nm), and a biosample (urine) layer, the proposed sensor comprises of five layers. The selection of the sequence and dimensions of both…

INTRODUCTION: No clinical studies to date have analyzed the critical shoulder angle (CSA) following anterior acromioplasty. Our study's main objective was to measure the change in the CSA after acromioplasty. MATERIALS AND METHODS: Ninety patients were included in this retrospective series. The CSA and the type of acr…

PURPOSE: To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS: According to PR…

BACKGROUND: To follow the weight bearing foot posture in subjects, a measurement tool using digital photography was developed, Foot Build Registration System (FBRS) (Fig. 1) [M. Van der Cruijsen, Voetvorm registratie systeem, Boxmeer (1999).]. This study's objective was to investigate the reproducibility of FBRS measur…

Meta analysis is a collection of quantitative methods devoted to combine summary information from related but independent studies. Because research reports usually present only data reductions and summary statistics rather than detailed data, the reviewer must often resort to rather crude methods for constructing summa…

In 1988 we did develop an EDP-System for data collection of daily routine documentation, which allows on the one hand a complete registration and on the other hand only offers entire and plausible data because of the logical program structure. The registered data are saved in a data bank structure as well as in report…

OBJECTIVE: Mental disorders are prevalent among the population and seriously endanger people's working ability as well as their physical and mental health. This study employed stratified cluster random sampling to examine occupational stress, musculoskeletal disorders (MSDs) and the mental health status of 1675 coal mi…

American black bears survive winter months without food and water while in a mildly hypothermic, hypometabolic, and inactive state, yet they appear to be able to return to near-normal systemic function within minutes of arousal. This study's goal was to characterize the cardiovascular performance of overwintering black…

Sclerostin (SOST), a Wnt signaling pathway inhibitor, is involved in the pathogenesis of skeletal disorders. This study investigated the impact of the GKWWRPS motif on the PNAIG motif in Loop 2 of SOST, which is accountable for the interactions with the LRP6 protein that triggers the down-regulation of the Wnt signalin…

This letter to the editor identifies a critical methodological concern in a recent clinical trial by Qin et al. that compared the emergence profiles of remimazolam and propofol in pediatric anesthesia. We argue that the study's findings are confounded by a fundamental"asymmetry in interventions". The remimazolam group…

In the context of an international trend of cannabis legalisation and regulation, Switzerland is now allowing strictly supervised local pilot trials of cannabis sales. One of these is the Cann-L project in Lausanne, which will evaluate the impact on cannabis consumption of an access to a non-profit, public health-orien…

The authors examined the psychological factors associated with self-excoriative behavior among 56 women (mean +/- SE age: 24.0 +/- 1.0 years) with mild-to-moderate facial acne vulgaris. Ratings associated with poor self-concept, such as perfectionistic and compulsive personality traits, correlated more strongly with se…

This study's purpose was to assess resistance to sexual aggression, from kissing/fondling to intercourse; to test the relative efficacy of three theoretical models (Victim Precipitation, Social Control, and Situational Blame) for predicting resistance to acquaintance rape. Seventy-five percent of the 206 university stu…

A growing body of work estimates the prevalence of childhood victimization among incarcerated people. The present study seeks to descriptively and quantitatively summarize this abundant literature by reviewing studies that report childhood victimization prevalence among people incarcerated in the United States. The rev…

BACKGROUND: The literature indicates few studies on kidney patients' perception of the donor kidney. In light of this fact, we decided to explore this issue with adult patients. METHODS: We carried out a phenomenological study with 40 adult kidney patients. RESULTS: In this study, three main themes became apparent: t…

The article by St. Pierre et al provides valuable insights into the challenges faced by caregivers of individuals with Christianson syndrome (CS), focusing on emotional burden, symptom progression, and coping strategies. However, several key areas require further exploration. The study's limited sample size and lack of…

PURPOSE: This review aimed to synthesize existing research on the prevalence of Child Sexual Exploitation and Abuse (CSEA) in schools, while also identifying key moderators that influence these rates. METHODS: A comprehensive database search from 2012 to 2022 was conducted. Subgroup analyses and meta-regression were p…