5,082,726 papers found

BACKGROUND: The guidance on SUI has not been rigorously assessed using GRADE system. OBJECTIVE: To determine if the quality and results of existing systematic reviews on conservative treatment of stress urinary incontinence (SUI) can underpin evidence-based recommendations for practice. STUDY DESIGN: Review of system…

STUDY DESIGN: Review of publications. OBJECTIVE: To assess the level of physical capacity (peak oxygen uptake, peak power output, muscle strength of the upper extremity and respiratory function) in wheelchair-dependent persons with a spinal cord injury (SCI). SETTING: Erasmus MC, University Medical Centre Rotterdam,…

BACKGROUND: Clinical practice guidelines endorse arteriovenous fistulae (AVF) as the preferred form of vascular access. Despite recent advancements, concerns persist regarding variable AVF patency rates. This umbrella review aimed to evaluate and synthesize evidence on interventions and strategies associated with impro…

OBJECTIVES: As part of an effort to develop an extension of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement for living systematic reviews (LSRs), we discuss conceptual issues relevant to the reporting of LSRs and highlight a few challenges. METHODS: Discussion of conceptu…

INTRODUCTION: Systematic reviews and meta-analyses are important in shaping clinical practice, but the underlying quality of these studies is critical. The PRISMA guidelines for the reporting of systematic reviews, published in 2009, aimed to improve the quality of reporting of these studies. We looked at whether the r…

The quality of interventions can affect the results of clinical trials. Reviews of complex interventions need to take this into account

CONTEXT: Chronic kidney disease (CKD) is a major clinical kidney disease associated with numerous adverse events, such as heart failure and premature mortality. Dietary modifications are prioritized in the management of CKD due to the long-term effects of this disease. OBJECTIVE: In this review we sought to consolidat…

BACKGROUND: This is an update of a Cochrane overview published in Issue 9, 2011; that overview considered both efficacy and adverse events. This overview considers adverse events, with efficacy dealt with in a separate overview.Thirty-nine Cochrane reviews of randomised trials have examined the adverse events associate…

BACKGROUND: Acute decompensated heart failure (ADHF) is associated with inflammation. Inflammatory biomarkers in patients with ADHF are associated with increased mortality. Glucocorticoids mitigate systemic inflammation and may therefore have a therapeutic role in ADHF. We aim to investigate the effects of adding gluco…

OBJECTIVES: To evaluate the efficacy and safety of advanced therapeutic approaches for inherited retinal disease (IRD) using evidence from systematic reviews and meta-analyses. DESIGN: Umbrella review. DATA SOURCES: We searched for Epistemonikos, PubMed, Scopus, PsycInfo, Google Scholar, Joanna Briggs Institute Evide…

BACKGROUND: Early intervention following mental health symptom onset has great potential in reducing the long-term burden on individuals, families and friends, and society. The main focus in service development and research has been on early intervention in psychosis, but advances have been made for some other mental h…

BACKGROUND: 5-aminosalicylates (5-ASAs) are commonly used in non-surgical patients with Crohn's disease (CD), especially in mild-to-moderate disease, despite current guidelines against their use. Despite this, the evidence regarding their efficacy is mixed, with conflicting findings in systematic reviews (SRs). AIMS:…