2,694 papers found

Infectious diseases remain a major global health challenge, and effective control depends on early and accurate diagnosis. However, conventional immunodiagnostic platforms rely heavily on mammalian antibodies, which may present limitations related to animal welfare, production, and nonspecific immunological interaction…

IntroductionDemand for systemic anti-cancer therapy (SACT) is increasing, placing pressure on cancer services, particularly aseptic capacity. Aseptic preparation is a safety-critical, regulated component of SACT delivery, and constraints pose risks to resilience and patient safety. In response, the UK SACT Board in 202…

PURPOSE: To map the state of the art regarding risk factors and assessment methods employed in the screening of fluency disorders in preschool children. RESEARCH STRATEGIES: A scoping review was conducted in accordance with the Joanna Briggs Institute guidelines and the PRISMA-ScR checklist. The guiding question was:…

The increasing demand for sustainable and antibiotic-free veterinary practices has stimulated interest in natural products such as clinoptilolite, ozone therapy, bee-derived products, and phytotherapy. This systematic review evaluates evidence from 2010 to 2026 regarding their clinical efficacy and mechanisms of action…

OBJECTIVE: To evaluate research exploring food policy, practice and provision in early childhood education and care (ECEC) settings, using the socio-ecological model (SEM). DESIGN: A scoping review was conducted in accordance with the Joanna Briggs Institute (JBI) Methodology for scoping reviews and the Preferred Repo…

INTRODUCTION: Systemic mastocytosis (SM) is a heterogeneous clonal disorder characterized by the accumulation of abnormal mast cells in various tissues, predominantly the bone marrow. Given the rarity of the disease, the available data in Romania are extremely limited. It is estimated that the total number of diagnosed…

BACKGROUND: Knee osteoarthritis (KOA) is the most widespread degenerative disease in the cumulative population. With the increasing aging of the population, KOA has become one of the most important factors leading to joint deformities in middle-aged and elderly people. At present, the therapeutic effect of synovial mes…

OBJECTIVE: This review consolidates current knowledge on dentist-supervised tooth bleaching for vital teeth, drawing from systematic reviews, meta-analyses, and randomized clinical trials (RCTs) that followed CONSORT guidelines. DATA RESOURCES: MeSH and free terms like "tooth bleaching," "tooth whitening," "randomized…

BACKGROUND: Identification of real-time adverse drug reactions [ADRs] (as opposed to the risk of ADRs) in older poly-medicated people in primary care is a challenging task, often undertaken without an explicit strategy. This systematic review aims to evaluate replicable instruments and methods for identifying and addre…

AIM: This narrative review synthesizes current evidence on the association between Celiac disease (CD) and pulmonary disorders, explores underlying mechanisms, and highlights clinical implications and future research directions. BACKGROUND: CD is a chronic autoimmune enteropathy triggered by gluten ingestion in geneti…

The connection between diet and migraine has gained increasing attention in migraine research due to its potential relevance as part of migraine treatment. This study reviewed the current evidence on the use of diets or specific foods in the prevention of migraine.A PubMed search was performed with the keywords "diet a…

BACKGROUND: Stereotactic Ablative Radiotherapy (SABR) for the treatment of oligometastatic disease can improve survival and delay the requirement for systemic therapy. The benefits of SABR in oligoprogressive disease are less well-defined. Here, we evaluate the available evidence investigating the efficacy of SABR in t…

In some laboratories, mosquitoes' direct blood-feeding on live animals has been replaced with various membrane blood-feeding systems. The selection of blood meal sources used in membrane feeding is crucial in vector mass rearing as it influences the mosquitoes' development and reproductive fitness. Therefore, this scop…

BACKGROUND: Podcasts have become increasingly utilized in medical education over the past decade, especially in orthopaedic surgery. Compared with more traditional learning tools, podcasts are easily accessible, free, and capable of use while multitasking. Despite these apparent benefits, the effectiveness of podcasts…

We aimed to characterize knowledge and attitudes about rapid whole genome sequencing (rWGS) implementation of a broad constituency of healthcare professionals at hospitals participating in a statewide initiative to implement rWGS for hospitalized neonates and children up to 18 years of age meeting clinical criteria for…

BACKGROUND: The rapid uptake of digital technology into the operating room has the potential to improve patient outcomes, increase efficiency of the use of operating rooms, and allow surgeons to progress quickly up learning curves. These technologies are, however, dependent on huge amounts of data, and the consequences…

BACKGROUND: Oxaliplatin represents a main component of cytotoxic treatment regimens in colorectal cancer (CRC). Given its efficacy, oxaliplatin is frequently re-administered in the context of the continuum of care in metastatic CRC (mCRC). However, efficacy and tolerability of this therapeutic strategy has not been com…

BACKGROUND AND AIM: Enteral nutrition (EN) is applicable to adult Crohn's disease (CD) in treating malnutrition and in inducing remission - here as a less effective alternative than corticosteroids. The purpose of this review is to determine whether preoperative EN impacts postoperative complications of adult CD, eithe…

Severe trauma constitutes a major cause of death and disability, especially in younger patients. The cerebral autoregulatory capacity only protects the brain to a certain extent in states of hypovolemia; thereafter, neurological deficits and apoptosis occurs. We therefore set out to investigate neuroprotective strategi…

Prostate cancer is a heterogeneous disease whose therapies frequently have adverse effects. Informed patient counseling regarding likely clinical outcomes is therefore important. In this systematic review we aimed to identify all external validations of tools that are used to predict clinical outcomes in patients under…