2,645 papers found

BACKGROUND: The US Central Command (CENTCOM) area of responsibility (AOR) spans 20 nations in the Middle East, Central, and South Asia. Evacuations outside this AOR include all injury types and severities; however, it remains unclear what proportion of evacuations were due to disease and non-battle injuries (DNBI). Und…

AIM: To determine if robotic gait training for individuals with cerebral palsy is more effective than the standard of care for improving function. METHOD: PubMed, Embase, Scopus, and Cochrane databases were searched from 1980-January, 2022 for articles that investigated robotic gait training versus standard of care (i…

BACKGROUND: Neoadjuvant chemotherapy is the standard of care before radical cystectomy for muscle invasive bladder cancer. Recently, checkpoint inhibitors have been investigated as a neoadjuvant treatment after the reported efficacy of checkpoint inhibitors in metastatic urothelial carcinoma. OBJECTIVES: The aim of th…

PURPOSE: Melphalan is a bifunctional alkylating agent that elicits its cytotoxic activity by rapidly forming an initial DNA monoadduct, which then produces an inter-strand crosslink. Most studies exploring the role of inherited differences in DNA repair and melphalan outcomes focus on inter-strand crosslink repair, how…

Hair loss is a complex and multi-factorial problem that is associated with significant psychological morbidity in women. Menopausal women represent a significant percentage of those affected, since the menopausal hormonal transition can be a contributing factor. A novel nutraceutical supplement has been specifically fo…

Ketogenic diets (KDs) have received increasing attention among athletes and physically active individuals. However, the question as to whether and how the diet could benefit this healthy cohort remains unclear.This study was designed to systematically review the existing evidence concerning the effect of KDs on body co…

The oligometastatic state is a proposed entity between localized cancer and widely metastatic disease, comprising an intermediate subset of metastatic cancer patients. Most data to support locally-directed treatment, such as stereotactic ablative radiotherapy (SABR), for oligometastases are from retrospective instituti…

OBJECTIVES: This systematic review aimed to evaluate evidence on the relation between the caregivers' oral health condition and dental caries prevalence in their offspring. MATERIALS AND METHODS: Scientific literature was searched in PubMed, Scopus, LILACS, Web of Science, the Cochrane Library databases, and Grey Lite…

IMPORTANCE: A 31-gene expression profile (31-GEP) test to predict metastatic risk in patients with cutaneous malignant melanoma has previously been validated and is available for clinical use. The impact of the availability of such a test on clinical decision-making has previously been studied. However, little is known…

OBJECTIVES: The present study aimed to gain more insight into, and summarise, blood donation determinants among migrants or minorities of Sub-Saharan heritage by systematically reviewing the current literature. BACKGROUND: Sub-Saharan Africans are under-represented in the blood donor population in Western high-income…

BACKGROUND: Health professionals may advise women to either stop breastfeeding or drug treatment due to restrictive advice in drug monographs. Regional medicines information and pharmacovigilance centres in Norway (RELIS) provide free and industry-independent answers to questions about drugs and breastfeeding documente…

BACKGROUND: Mesh infection after abdominal hernia repair is a devastating complication that affects general and plastic surgeons alike. The purpose of this study was 3-fold: (1) to determine current evidence for treatment of infected abdominal wall mesh via systematic review of literature, (2) to analyze our single-ins…

The definition of acute pyelonephritis is controversial. There are two contrasting approaches: (1) acute pyelonephritis is a severe infectious disease involving the kidney parenchyma, and specific imaging techniques are required for diagnosis; (2) acute pyelonephritis is a urinary tract infection, and diagnosis and the…

BACKGROUND: Progression independent of relapse activity (PIRA) is increasingly appreciated as one of the important factors contributing to disability accumulation in MS. sGFAP and sNfL could represent markers reflecting two separate biological processes related to relapse-independent progression in MS. OBJECTIVE: To p…

IntroductionDemand for systemic anti-cancer therapy (SACT) is increasing, placing pressure on cancer services, particularly aseptic capacity. Aseptic preparation is a safety-critical, regulated component of SACT delivery, and constraints pose risks to resilience and patient safety. In response, the UK SACT Board in 202…

PURPOSE: To map the state of the art regarding risk factors and assessment methods employed in the screening of fluency disorders in preschool children. RESEARCH STRATEGIES: A scoping review was conducted in accordance with the Joanna Briggs Institute guidelines and the PRISMA-ScR checklist. The guiding question was:…

The increasing demand for sustainable and antibiotic-free veterinary practices has stimulated interest in natural products such as clinoptilolite, ozone therapy, bee-derived products, and phytotherapy. This systematic review evaluates evidence from 2010 to 2026 regarding their clinical efficacy and mechanisms of action…

OBJECTIVE: To evaluate research exploring food policy, practice and provision in early childhood education and care (ECEC) settings, using the socio-ecological model (SEM). DESIGN: A scoping review was conducted in accordance with the Joanna Briggs Institute (JBI) Methodology for scoping reviews and the Preferred Repo…

INTRODUCTION: Systemic mastocytosis (SM) is a heterogeneous clonal disorder characterized by the accumulation of abnormal mast cells in various tissues, predominantly the bone marrow. Given the rarity of the disease, the available data in Romania are extremely limited. It is estimated that the total number of diagnosed…

BACKGROUND: Knee osteoarthritis (KOA) is the most widespread degenerative disease in the cumulative population. With the increasing aging of the population, KOA has become one of the most important factors leading to joint deformities in middle-aged and elderly people. At present, the therapeutic effect of synovial mes…