5,003,108 papers found

BACKGROUND: Occupational exposure accounts for the second preventable risk factor for bladder cancer (BC), after smoking. OBJECTIVE: This study aimed to extract evidence-based data from the systematic reviews that included studies primarily from the past 30 years, based on a clearly defined method of exposure assessme…

PURPOSE: The purpose of this umbrella review was to systematically evaluate the effectiveness of therapeutic strategies for managing low anterior resection syndrome following sphincter-preserving surgery for rectal cancer and to provide evidence-based recommendations for clinical practice. METHODS: A systematic litera…

BACKGROUND: Psychosocial and pharmacological interventions can effectively treat eating disorders (EDs), but improvements are often short-term and modest. Neuromodulation, altering nerve activity through targeted neurological stimulation, is an emerging intervention in neuropsychiatric disorders. This meta-review synth…

OBJECTIVE: Clinicians treating patients with patellofemoral pain (PFP) rely on consensus statements to make the best practice recommendations in the absence of definitive evidence on how to manage PFP. However, the methods used to generate and assess agreement for these recommendations have not been examined. Our objec…

BACKGROUND: Low-intensity cognitive behavioural therapy (LICBT) has been recommended as a primary intervention in the tiered care for mild to moderate generalised anxiety disorder. However, LICBT for generalised anxiety disorder are markedly diverse and efficacy data on various outcomes have not been systematically rev…

The idea that risk for psychiatric disorders may be transmitted intergenerationally via prenatal programming places interest in the prenatal period as a critical moment during which intervention efforts may have a strong impact, yet studies testing whether prenatal interventions also protect offspring are limited. The…

INTRODUCTION: Productivity loss may contribute to a large proportion of costs of health conditions in an economic evaluation from a societal perspective, but there is currently a lack of methodological consensus on how productivity loss should be measured and valued. Despite the research progress surrounding this issue…

BACKGROUND & OBJECTIVE: It has been suggested that prenatal vitamin D plays a role in the development of childhood asthma and wheeze. Several systematic reviews have been conducted, but the results are inconsistent, and the methodological quality has not been studied. Therefore, the objective of this umbrella review wa…

PURPOSE: Side-effects of adjuvant endocrine therapy (AET) are common in breast cancer survivors, and can affect adherence to treatment. We synthesised the evidence for strategies to self-manage these side-effects. METHODS: We searched for systematic reviews and clinical guidelines on self-management strategies for AET…

BACKGROUND: Cancer-related fatigue is one of the most prevalent and distressing symptoms among cancer patients, resulting in a great cancer research challenge. Numerous systematic reviews of physical training interventions have been conducted to find the most effective approach. However, evidence remains fragmented, an…

BACKGROUND: Perinatal depression is a high prevalent mental health problem with serious consequences. Evidence about effective psychological interventions in treating perinatal depression has been increasing, but it lacks a comprehensive synthesis of findings. METHODS: A systematic review of systematic reviews and met…

OBJECTIVES: To describe the results of a mapping review exploring the coverage of unwanted treatment effects in systematic reviews of the effects of various treatments for moderate to severe depression in children and adolescents. SETTING: Any context or service providing treatment for depression, including interventi…

OBJECTIVES: The aim of the study was to characterize methodological conduct, reporting, and quality of five knowledge synthesis (KS) approaches. STUDY DESIGN AND SETTING: Retrospective analysis of a convenience sample of five published databases of KS approaches: overview of reviews (n = 74), scoping reviews…

BACKGROUND: Estimates of energy requirements are needed in weight management and are usually determined using prediction equations. The objective of these two systematic reviews was to identify which equations based on simple anthropometric and demographic variables provide the most accurate and precise estimates of (1…

The 6th ITI Consensus Conference was held in Amsterdam on 17-19 April 2018. In preparation for the conference, 21 systematic reviews were written. They were divided into five main topics in dental implantology-surgery, prosthodontics, patient-reported outcomes, complications/risk and digital technologies. Based on thes…

BACKGROUND: Cervical cancer poses a major public health burden in low- and middle-income countries, especially in Africa, despite being largely preventable through HPV vaccination and screening. This umbrella review synthesizes findings from systematic reviews and meta-analyses to identify factors influencing screening…

BACKGROUND: In this umbrella review, we systematically evaluated the evidence from meta-analyses and systematic reviews of maternal factors associated with low birth weight. METHODS: PubMed, Scopus, and Web of Science were searched to identify all relevant published studies up to August 2023. We included all meta-anal…

A systematic review with meta-analysis (SRMA) represents the pinnacle of evidence, but its validity depends on methodological rigor. This narrative review synthesizes recommendations from major reporting frameworks- Preferred Reporting Items for Systematic Reviews and Meta‑Analyses 2020 (PRISMA‑2020), Met…

The number of literature reviews in the fields of ecology and conservation has increased dramatically in recent years. Scientists conduct systematic literature reviews with the aim of drawing conclusions based on the content of a representative sample of publications. This requires subjective judgments on qualitative c…

BACKGROUND: The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach is used to assess the certainty of evidence in systematic reviews and meta-analyses. METHODS: We describe how the GRADE approach is used in systematic reviews and meta-analyses, including key points and examples. This ov…