2,694 papers found

BACKGROUND: Acute kidney injury is associated with high mortality, and the optimal time to start renal replacement therapy for acute kidney injury is unknown despite several randomised controlled trials on the subject. We performed a systematic review and meta-analysis to assess the effect of earlier initiation of rena…

Surgery is the first-line therapy for treatment of cutaneous squamous cell carcinoma (cSCC), and interventional radiotherapy is recommended when surgery is not feasible, contraindicated, or refused by the patient. To provide a multidisciplinary systematic review of the role of interventional radiotherapy for the treatm…

There is no recent comprehensive overview of contemporary clinical trials assessing short and long-term outcomes in patients with acute coronary syndrome (ACS). This paper reviews factors from recent clinical trials that influenced prognosis in patients with ACS. Cochrane and PubMed databases were screened systematical…

BACKGROUND: To systematically evaluate the efficacy and safety of basic fibroblast growth factor (bFGF) in the treatment of burns and to provide evidence-based medical information for clinicians to choose the appropriate treatment measures for burns. METHODS: Seven databases, including PubMed, the Cochrane Library, Em…

INTRODUCTION: Little is known about the adoption of evidence-based practice (EBP) by yoga therapists (YTs). OBJECTIVE: To determine the attitudes, skills, training, use, barriers and facilitators to the use of EBP amongst North American YTs DESIGN: Cross-sectional, descriptive survey METHODS: Self-identified YTs pract…

PURPOSE: The development of recommendations for advancing automated i.v. medication compounding is described. SUMMARY: Managing the shift from manual to robotic compounding of i.v. therapies requires an awareness of how automation affects practice and how to best implement robotics into current practice. An internatio…

OBJECTIVES: The aim of this systematic review was to evaluate the efficacy of different soft tissue augmentation/correction methods in terms of increasing the peri-implant width of keratinized mucosa (KM) and/or gain of soft tissue volume during second-stage surgery. MATERIALS AND METHODS: Screening of two databases,…

BACKGROUND: A pathologic complete response (pCR) can sometimes be induced by intensive or long-term neoadjuvant chemotherapy (NAC). This prognostic research study based on a systematic review of the literature evaluated the impact of a pCR on the long-term survival of gastric cancer (GC) patients. METHODS: Articles we…

BACKGROUND: Management of recurrent Clostridium difficile-associated disease (CDAD), particularly in elderly patients, remains clinically challenging. Faecal transplantation (FT) may restore normal microbiota and break the cycle of recurrent CDAD. AIM: To critically appraise the clinical research evidence on the safet…

OBJECTIVES: The aim of this study was to evaluate the efficacy of supervised physiotherapy supplemented with non-steroidal antiinflammatory drugs (NSAIDs) for treating adhesive capsulitis. BACKGROUND: Even though adhesive capsulitis is a common disorder, literature on its treatment is still limited. METHODS: Forty-fi…

OBJECTIVES: To critically analyze the experience of clinical clerkship students exposed to simulator-based teaching, in order to better understand student perspectives on its utility. METHODS: A convenience sample of clinical students (n = 95) rotating through an emergency medicine, surgery, or longitudinal patient-do…

BACKGROUND AND AIMS: Alcohol use disorder (AUD) is a common and debilitating condition in Western countries. AUD is often stigmatized, which can worsen the condition and be a barrier for treatment seeking. This is a systematic review that aimed to identify and analyze stigmatizing attitudes and behaviors of physicians…

Systematic reviews play a critical role in evidence-based research but are labor-intensive, especially during title and abstract screening. Compact large language models (LLMs) offer potential to automate this process, balancing time/cost requirements and accuracy. The aim of this study is to assess the feasibility, ac…

BACKGROUND: Acute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, with significant advancements in treatment leading to over 90% five-year event-free survival rates in developed countries. However, disruptions in health behaviors during treatment, such as diet, activity, and sleep, can negatively impa…

INTRODUCTION: Women who live in humanitarian settings are three times more likely to die than those who live in peaceful environments. Person-centred maternity care (PCMC) is a fundamental human right for every woman, yet it is often overlooked in humanitarian contexts. This scoping review aims to summarise person-cent…

OBJECTIVE: We aim to describe the current programmatic structure and learning environment of US neonatal-perinatal medicine (NPM) fellowship programs. STUDY DESIGN: All U.S. NPM program directors (PDs) and associate program directors (APDs) were surveyed. Descriptive statistics for quantitative questions and thematic…

As pediatric palliative care (PPC) expands within institutions and nationally, little guidance is available on building outpatient programs.We asked outpatient PPC (OPPC) program leaders in the United States about clinic development experiences to gather advice for growing programs.As part of a larger OPPC study, 48 fr…

BACKGROUND: Diabetes mellitus is a complex metabolic disorder that has an enormous impact on people's quality of life and health. Although there is no doubt about the effectiveness of oral hypoglycemic agents combined with lifestyle management in controlling diabetes, no individual has ever been reported to have been c…

Human immunodeficiency virus (HIV) is a viral infection which progressively leads to acquired immunodeficiency syndrome (AIDS) in the absence of treatment. This happens through the destruction of crucial cells in the immune system, such as the helper T cells, dendritic cells, and macrophages. Since the first case…

INTRODUCTION: Despite policies aiming at universal health coverage by ensuring availability and accessibility of general practitioners (GPs), medically underserved areas are still present in Europe. This systematic review aims to summarize and compare literature on interventions and their potential effectiveness of GP…