2,530 papers found

Valvular heart disease represents a significant burden on global health, and its impact on health-related quality of life (HRQOL) is increasingly recognized in clinical decision-making. This integrative review synthesized outcomes measured with the 36-Item Short Form Health Survey (SF-36). A structured PubMed search wa…

Achilles tendon defects represent a challenging reconstructive problem in both athletic and comorbid populations. The objective of this review was to evaluate the versatility, clinical utility, and patient-centered outcomes of Achilles tendon-based flaps and reconstructions across trauma, chronic rupture, sports medici…

BACKGROUND: Free Open Access Medical Education has the potential to democratize access to medical knowledge globally; however, this potential remains largely unrealized, particularly in resource-limited settings. Content is increasingly concentrated on a small number of platforms, each hosting large volumes of material…

Intraoperative neuromonitoring of the facial nerve (cranial nerve VII) is critical during skull base surgery due to the nerve's proximity to surgical pathologies and the significant morbidity associated with a facial nerve injury. Objective: This systematic review aims to summarize and describe the numerous intraoperat…

OBJECTIVE: We performed a systematic review on the localizing value of ictal hypersalivation and ictal spitting in focal epilepsy with the aim of summarizing the state-of-the-art anatomo-clinical correlations in the field and aiding the interpretation of ictal semiology within the framework of pre-surgical evaluation.…

Given the significant economic and social burden of osteoporosis, there is growing interest in developing an efficient alternative to the traditional dual-energy X-ray absorptiometry (DXA). Radiofrequency Echographic Multi Spectrometry (REMS) is an innovative, non-ionizing imaging technique that recently emerged as a v…

BACKGROUND: Overweight and obesity in pregnancy are associated with health risks for women and babies. Providing effective weight management during pregnancy is necessary to support appropriate gestational weight gain and improve outcomes for women and their infants. This study aimed to synthesise evidence documenting…

PURPOSE: This manuscript performed a meta-analysis to compare the effects of a low-fat diet (LFD) and a low-carbohydrate diet (LCD) on body weight and lipid levels in adolescents with overweight and obesity. PATIENTS AND METHODS: PubMed and other databases were searched for the full-text literature comparing LFD and L…

INTRODUCTION AND OBJECTIVE: Sci-Hub is a website that allows users to download full-text versions of millions of scientific articles for free. The objective of this study was to evaluate the association between the use of Sci-Hub and consultation of scientific journals by medical students from six Latin American countr…

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has resulted in substantial impacts on all aspects of medical education. Modern health systems must prepare for a wide variety of catastrophic scenarios, including emerging infectious disease outbreaks and human and natural disasters. During the COVID-19 pand…

BACKGROUND: Cancer treatment often results in financial burdens for patients including healthcare costs as well as treatment-induced disability leading to "financial toxicity" (FT) and decreased quality of life. The purpose of this review is to describe FT related to head and neck cancer (HNC) treatment, including quan…

BACKGROUND: Vaccine hesitancy is not a new phenomenon to Pakistan. This is evidenced through the slow progress of previous vaccination campaigns and programs against MMR, BCG, and especially polio. This issue continues to persist and is therefore becoming the cause of low COVID-19 vaccination rates in Pakistan. AIM: T…

Circulating tumor DNA (ctDNA) is increasingly being used as a biomarker in early breast cancer (EBC). We performed a systematic review and meta-analysis to investigate the prognostic value of ctDNA in patients with EBC treated with neoadjuvant therapy (NAT). We searched Medline, Web of Science and Embase for observatio…

BACKGROUND: Clostridium collagenase histolyticum (CCH) is being evaluated in women as a cellulite treatment. OBJECTIVE: To report preclinical safety and human pharmacokinetics (PK) and safety data for CCH. METHODS: Across 3 PK studies, 41 women received 12 subcutaneous injections per thigh/buttock in 1 session (up to…

BACKGROUND: Myosteatosis has been reported to be a novel biomarker that could predict survival outcomes in patients with colorectal cancer. However, results have been conflicting. This systematic review and meta-analysis aimed to evaluate the long-term impact of myosteatosis on the survival of these patients. METHODS:…

OBJECTIVES: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2018. METHOD: A bibliographic search using a combination of MeSH descriptors and free-text terms on CRI was performed using PubMed, followed by a double-blind review…

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Once metastasized, prognosis is poor despite regular treatment with conventional cytotoxic drugs. This study reviews the preclinical and clinical results of non-cytotoxic systemic therapy in MPNST. METHODS: A systematic…

Psoriasis is a chronic, systemic, inflammatory disease with manifestations resulting from a dysregulated immune response. In psoriatic skin, expression of all phosphodiesterase 4 (PDE4) isoforms (A-D), part of a family of enzymes known to regulate cyclic adenosine monophosphate levels and immune homeostasis, is elevate…

BACKGROUND: Heart failure (HF) is a major cause of mortality and disability in type 2 diabetes mellitus (T2DM). This study sought to improve the assessment of HF risk in patients with T2DM-a step that would be critical for effective HF screening. METHODS: A systematic literature search was performed on electronic data…