97,335 papers found

BACKGROUND: There has been a rapid proliferation of FDA-approved medications with labeled indications for skin cancer over the last decade, with particular growth over the last 5 years. OBJECTIVE: We aimed to evaluate the impact of an evolving U.S. regulatory framework on drug development programs to better understand…

OBJECTIVE: To directly compare the predictive powers of somatosensory evoked potentials (SEPs) to those of motor and pupillary responses. DESIGN AND SETTING: Prospective clinical study in a paediatric intensive care unit. PATIENTS AND PARTICIPANTS: 102 severely brain-injured children less than 15 years of age. MEASU…

American expectations for health care over the last 30 years have been developed during the most massive transfer of wealth into one sector that history has ever seen. American expenditures for health have been growing for the last 40 years at two and one half times the rate of inflation, which defies the law of econom…

BACKGROUND: Splenectomy is frequently performed in transfusion-dependent thalassemia (TDT) patients to lower blood transfusion needs but is associated with significant long-term complications, including sepsis, thrombosis, and pulmonary hypertension. This study examines the long-term complications, survival rates, and…

BACKGROUND: Idiopathic Generalized Epilepsies (IGE) are a subset of syndromes defined by the International League against Epilepsy (ILAE) with the particularity to respond to a narrow number of ASMs and particularly to valproic acid (VPA). Recommendations have changed in the last decade. We aimed to describe changes in…

BACKGROUND: For patients with metastatic cancer, treatment with palliative chemotherapy can lead to more aggressive end-of-life (EOL) care. This retrospective study aimed to assess the time from the last chemotherapy treatment to death and investigate the variables associated with the delivery of palliative chemotherap…

OBJECTIVES: Dental implants shorter than 8 mm, called short dental implants (SDIs), have been considered to have a lower success rate than standard length implants. But recent studies have shown that SDIs have a comparable success rate, and implant diameter was more important for implant survival than implant length. A…

Hematopoietic cell transplantation is an established treatment option with curative potential for a variety of clinical conditions. The last decade especially witnessed a remarkable increase in HCT activity in Turkey. In 2014, 696 pediatric and 2631 adult (total 3327) HCT were performed in Turkey. Corresponding transpl…

The relevant literature on cerebrovascular diseases from the Indian subcontinent in the last 35 years has been reviewed. Most of the data available are from retrospective studies carried out in various large urban hospitals. The incidence of stroke reported is less when compared with western figures, which may be a ref…

Many new insights have been gained over the past 5 years into the mechanisms that regulate immune reactivity to cell and organ transplants. This new knowledge is being applied to the development of innovative experimental strategies that may soon be evaluated in the clinic.

PURPOSE: To determine the lifetime risk and duration of blindness in patients with manifest open-angle glaucoma (OAG). DESIGN: Retrospective chart review. METHODS: We studied glaucoma patients who died between January 2006 and June 2010. Most glaucoma patients living in the catchment area (city of Malmö; n = 305…

Bronchiectasis, a chronic lung disease characterised by cough and purulent sputum, recurrent infections, and airway damage, is associated with considerable morbidity and mortality. To date, treatment options have been limited to physiotherapy to clear sputum and antibiotics to treat acute infections. Over the last deca…

The last 20 years of the last century, that sounds long ago but was actually the time that many of us already practiced in Rhinology or received their training, was I think the time of endoscopic sinus surgery. We learned all the possibilities of the endoscope, first mainly in limited inflammatory disease but later als…

In the last decade, more than 1.5 million children have died as victims of war and 2000 over 300,000 children were being used as combatants. Colombia, the fourth largest country in Latin America in terms of population and second in area, has been the site of conflict between the government and guerrilla groups, which h…

BACKGROUND/OBJECTIVES: Published prevalences of depression are mainly based on measurements of depressive symptoms, whereas data on clinical depressions are lacking. Our aim was to map the prevalence of ICD-10 diagnoses of depression made by physicians in routine healthcare, during the last year of life in non-cancer c…

The examination sample was a group of 1592 children of 3 to 6 years of age (787 boys and 805 girls). Aim of the examination was to gather information about the rate and intensity of caries cases of Capital kindergartners. The results permit to state that the rate and intensity of caries show a declining tendency in the…

The results of clinical examination and treatment of 751 patients with rectal cancer are presented. A total of 684 (91.0%) patients underwent radical surgery. In 439 (64.2%) from them sphincter saving operations were carried out. The rate of sphincter saving procedures for the last 5 years has increased up to 73.8%, mo…

OBJECTIVE: To introduce a percutaneous transcalcaneal reconstruction technique for the treatment of acute Achilles tendon insertion avulsion, and to assess its short-term effectiveness. METHODS: Between January 2014 and June 2020, 25 patients with acute Achilles tendon insertion avulsion were treated with the percutan…

This follow-up study investigated whether attitudes toward the metric system have changed over the last 15 years. 132 subjects ranging in age from 18 to 45 years participated by filling out a 7-item survey designed to measure attitudes toward the metric system. Each survey item was scored using a 5-point rating, e.g.,…

A review of the 746 cesarean sections performed at the University of California Hospital from 1907 through 1948 shows an overall cesarean section incidence of 3.91 per cent. The maternal mortality rate associated with these cesarean sections has been 1.61 per cent. There has been a steady decline in mortality over the…