2,589 papers found

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has resulted in substantial impacts on all aspects of medical education. Modern health systems must prepare for a wide variety of catastrophic scenarios, including emerging infectious disease outbreaks and human and natural disasters. During the COVID-19 pand…

BACKGROUND: Cancer treatment often results in financial burdens for patients including healthcare costs as well as treatment-induced disability leading to "financial toxicity" (FT) and decreased quality of life. The purpose of this review is to describe FT related to head and neck cancer (HNC) treatment, including quan…

BACKGROUND: Vaccine hesitancy is not a new phenomenon to Pakistan. This is evidenced through the slow progress of previous vaccination campaigns and programs against MMR, BCG, and especially polio. This issue continues to persist and is therefore becoming the cause of low COVID-19 vaccination rates in Pakistan. AIM: T…

Circulating tumor DNA (ctDNA) is increasingly being used as a biomarker in early breast cancer (EBC). We performed a systematic review and meta-analysis to investigate the prognostic value of ctDNA in patients with EBC treated with neoadjuvant therapy (NAT). We searched Medline, Web of Science and Embase for observatio…

BACKGROUND: Clostridium collagenase histolyticum (CCH) is being evaluated in women as a cellulite treatment. OBJECTIVE: To report preclinical safety and human pharmacokinetics (PK) and safety data for CCH. METHODS: Across 3 PK studies, 41 women received 12 subcutaneous injections per thigh/buttock in 1 session (up to…

BACKGROUND: Myosteatosis has been reported to be a novel biomarker that could predict survival outcomes in patients with colorectal cancer. However, results have been conflicting. This systematic review and meta-analysis aimed to evaluate the long-term impact of myosteatosis on the survival of these patients. METHODS:…

OBJECTIVES: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2018. METHOD: A bibliographic search using a combination of MeSH descriptors and free-text terms on CRI was performed using PubMed, followed by a double-blind review…

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Once metastasized, prognosis is poor despite regular treatment with conventional cytotoxic drugs. This study reviews the preclinical and clinical results of non-cytotoxic systemic therapy in MPNST. METHODS: A systematic…

Psoriasis is a chronic, systemic, inflammatory disease with manifestations resulting from a dysregulated immune response. In psoriatic skin, expression of all phosphodiesterase 4 (PDE4) isoforms (A-D), part of a family of enzymes known to regulate cyclic adenosine monophosphate levels and immune homeostasis, is elevate…

BACKGROUND: Heart failure (HF) is a major cause of mortality and disability in type 2 diabetes mellitus (T2DM). This study sought to improve the assessment of HF risk in patients with T2DM-a step that would be critical for effective HF screening. METHODS: A systematic literature search was performed on electronic data…

OBJECTIVE: This study aims to describe premature ovarian failure (POF)/primary ovarian insufficiency (POI) symptoms experienced by women from a non-clinic-based sample of members of a POF/POI-specific support group. METHODS: Two hundred ninety women were surveyed for 6 weeks. The survey included demographics, health h…

In 2007, the Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG07) were first published in the Journal of Hepato-Biliary-Pancreatic Surgery. The fundamental policy of TG07 was to achieve the objectives of TG07 through the development of consensus among specialists in this field throughout th…

AIMS AND BACKGROUND: Caveolin-1 is a key component of membrane caveolae which plays an important role in cell transformation, cell migration, metastasis and angiogenesis. The mechanism of caveolin-1 and VEGF-C in lymphatic metastasis of nonsmall cell lung cancer (NSCLC) is still unclear. This study aimed to define the…

The use of artificial intelligence (AI) in imaging departments is increasing in Europe. This study assesses the clinical value of an AI fracture algorithm by assessing ease of use, clinicians' trust, and perceived barriers and benefits of this decision support tool in daily practice across two emergency departments (ED…

BACKGROUND AND OBJECTIVE: Augmented reality (AR) is being increasingly integrated into spine surgery. However, most existing reviews predominantly focus on its use in instrumentation-based procedures. The broader role of AR in of non-instrumentation minimally invasive spine surgery (MISS), including decompression, endo…

TITLE: Ten-Year Survival of Posterior Teeth in Patients with Periodontitis Following Systematic Periodontal Treatment: A Systematic Review and Meta-analysis Using Only Open-Access Evidence and Analytic Tools Background OBJECTIVES: To determine whether conclusions drawn from open-access literature using freely available…

BACKGROUND CONTEXT: Given increasing use of both cervical pedicle screw (CPS) fixation in the subaxial cervical spine (C3-C7) and emerging navigation technologies, a quantitative profile of safety and accuracy remains wanting. Compared with lateral mass instrumentation of this region, CPS fixation shows superior biomec…

BACKGROUND: Renal insufficiency (RI) is a key factor affecting the prognosis of multiple myeloma (MM) patients. Because the benefit of daratumumab for treating MM patients with RI remains unclear, our objective was to evaluate the efficacy of daratumumab on MM patients with RI. METHODS: We conducted a systematic searc…

Retinopathy of prematurity (ROP) is a rare proliferative ocular condition that can happen in premature babies (born preterm&#xa0;<36 weeks)&#xa0;or who weigh <1.5 kg&#xa0;at birth (low birth weight babies). ROP is a major cause of childhood blindness. It is a premature disease&#xa0;since retina vascularization is compl…