5,082,997 papers found

BACKGROUND: This umbrella review, aimed to summarize systematic evidence on non-genetic risk indicators that are present at the start of pregnancy and their potential association with preterm birth. METHODS: We searched Medline and Embase up to June 30, 2021, for systematic reviews and meta-analyses of observational s…

PURPOSE: This umbrella review aimed to investigate the evidence for an association of dietary intake of total protein as well as animal and plant protein with the incidence of coronary heart disease (CHD), stroke and total cardiovascular diseases (CVD). METHODS: PubMed, Embase and Cochrane Database were systematically…

OBJECTIVES: To identify, summarize, and analyze published comments relevant to the PRISMA-P (Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocols) 2015 reporting guideline for systematic review protocols, with special emphasis on suggestions for guideline modifications. METHODS: We included doc…

INTRODUCTION: This umbrella review identified the current high-quality systematic reviews on e-cigarettes as a smoking cessation aid. What is the comparative effectiveness of e-cigarettes compared to other cessation treatments or approaches? We also investigated the systematic reviews for reporting biases. METHODS: Th…

BACKGROUND: Adverse pregnancy outcomes have reached epidemic proportions in recent years with serious health ramifications, especially for diverse cancers risk. Therefore, we carried out an umbrella review to systematically evaluate the validity and strength of the data and the extent of potential biases of the establi…

PURPOSE OF REVIEW: The aim of this study was to describe our knowledge about the use of epinephrine in cardiac arrest and discuss the unknowns and current controversies. RECENT FINDINGS: A recent large, well conducted, double-blind, randomized placebo-controlled trial of over 8000 patients with out-of-hospital cardiac…

BACKGROUND: Yolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sa…

We report a rare case of a 38-year-old woman with metastatic colonic adenocarcinoma from primary lung adenocarcinoma detected by PET/CT. She underwent colonoscopy and adenocarcinoma was diagnosed in the pathology report, which was the same as that for lymph node biopsy from a left supraclavicular lymph node. We used im…

Evidence-based practice merges the best and most relevant clinical research data with clinician experience, pathophysiology of disease state, and the specifics of individual patient care. Currently, there is a significant gap between the best research evidence in healthcare and application of this evidence to clinician…

BACKGROUND: Ewing's sarcomas account for approximately 10% of primary malignant bone tumors. While most of the primary Ewing's sarcomas occur in the long bones, pelvis, or ribs, approximately 1-6% of these sarcomas arise in the skull. We found approximately 50 cases of Ewing's sarcoma of the calvarium reported in our s…

This is the second of two articles exploring the meaning of 'evidence-based practice'. The first, in last month's issue, considered what is meant by 'evidence'. This month, Jan Draper examines how literature reviews can help nurses make sense of the variety of evidence available to them.

The use of research evidence depends on more than its quality. If one considers other factors that influence the use of evidence, the quantity of accessible evidence and initiatives ensuring a wider understanding of it must be equally important. In consequence, improving the quality of research evidence alone will not…

Systematic reviews of diagnostic accuracy studies can provide the best available evidence to inform decisions regarding the use of a diagnostic test. In this guide, the authors provide a practical approach for clinicians to appraise diagnostic accuracy systematic reviews and apply their results to patient care. The fir…

OBJECTIVE: To investigate the association between conflicts of interest and favourable recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews. DESIGN: Systematic review. ELIGIBILITY CRITERIA: Studies that compared the association between conflicts of interest and fav…

Studies showing favourable results tend to be published more than once. This practice of duplicate publication is, however, dishonest and unethical on the part of scientists and pharmaceutical companies. Inclusion into a meta-analysis of the results from multiple papers derived from one and the same controlled study gi…